Details of the Target

General Information of Target

Target ID LDTP17357
Target Name Tigger transposable element-derived protein 7 (TIGD7)
Gene Name TIGD7
Gene ID 91151
Synonyms
Tigger transposable element-derived protein 7
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAAELADTQLMLGVGLIEKDTNGEVLWVWCYPSTTATLRNLLLRKCCLTDENKLLHPFV
FGQYRRTWFYITIIEVPDSSILKKVTHFSIVLTAKDFNPEKYAAFTRILCRMYLKHGSPV
KMMESYIAVLTKGICQSEENGSFLSKDFDARKAYPAGSIKDIVSQFGMETVILHTALMLK
KRIVVYHPKIEAVQEFTRTLPALVWHRQDWTILHSYVHLNADELEALQMCTGYVAGFVDL
EVSNRPDLYDVFVNLAESEITIAPLAKEAMAMGKLHKEMGQLIVQSAEDPEKSESQVIQD
IALKTREIFTNLAPFSEVSADGEKRVLNLEALKQKRFPPATENFLYHLAAAEQMLKI
Target Bioclass
Other
Family
Tigger transposable element derived protein family
Subcellular location
Nucleus
Uniprot ID
Q6NT04
Ensemble ID
ENST00000396862.2
HGNC ID
HGNC:18331

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.G455S .
AN3CA SNV: p.I373T .
HCC70 SNV: p.S478C .
HT1376 SNV: p.G74E .
KYSE510 SNV: p.E34K; p.W87Ter .
PEO1 SNV: p.S518N .
RKO SNV: p.L504M .
SKOV3 SNV: p.Q104R .
SW756 SNV: p.L484F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C170(1.05)  LDD1573  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C170(1.05)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C170(1.18)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C170(0.90)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C170(0.81)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C170(1.16)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C170(1.13)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C170(1.25)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C170(0.98)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C170(1.41)  LDD1607  [1]
 LDCM0416  CL28 HEK-293T C170(1.21)  LDD1620  [1]
 LDCM0429  CL4 HEK-293T C170(0.90)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C170(1.05)  LDD1634  [1]
 LDCM0443  CL52 HEK-293T C170(0.99)  LDD1646  [1]
 LDCM0456  CL64 HEK-293T C170(1.56)  LDD1659  [1]
 LDCM0469  CL76 HEK-293T C170(0.91)  LDD1672  [1]
 LDCM0482  CL88 HEK-293T C170(1.14)  LDD1685  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402