Details of the Target
General Information of Target
| Target ID | LDTP17304 | |||||
|---|---|---|---|---|---|---|
| Target Name | Sialate:O-sulfotransferase 1 (WSCD1) | |||||
| Gene Name | WSCD1 | |||||
| Gene ID | 23302 | |||||
| Synonyms |
KIAA0523; Sialate:O-sulfotransferase 1; WSC domain-containing protein 1 |
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| 3D Structure | ||||||
| Sequence |
MGAKSMRSWCLCQICSCGSDYCPYEIVKQPRHVPEEYKPKQGKIDLGTTYKRDLNSYKVQ
PVAIVRPLERQVKKGKLDTVPTYKDDYRAWDLHKSELYKPEQTYHPPTVKFGNSTTFQDD FVPQEIKPRQSFKPSSVVKRSTAPFNGITSHRLDYIPHQLELKFERPKEVYKPTDQRFED LTTHRCDFQGLIGETAKLCRPVHTRVTQNALFEGSTEFRESFQPWEIPPPEVKKVPEYVP PTGSMLLNSTSHLDYVPYQANHVVPIRPVSQKRSNNFPFQGKSIMKEDFPAWESCRQGLI KKQQQIPNPSGKFDGLSTFRSHYVPHELIPTESCKPLNIAFKSSVPFDDVTMYSVEYTPK RQEICPASYPSPPGYIFDNTNSQGHKFFRKIIPAVKAF |
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| Target Bioclass |
Other
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| Family |
WSCD family
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| Subcellular location |
Golgi apparatus membrane
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| Function |
Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Displays selectivity toward glycolipids such as GM1 gangliosides.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
Jackson_1 Probe Info |
 |
20.00 | LDD0122 | [1] | |
|
DBIA Probe Info |
 |
C519(2.42) | LDD2469 | [2] | |
|
IA-alkyne Probe Info |
 |
C1055(0.00); C342(0.00); C36(0.00); C584(0.00) | LDD0161 | [3] | |
Competitor(s) Related to This Target
References