Details of the Target

General Information of Target

Target ID LDTP17250
Target Name Failed axon connections homolog (FAXC)
Gene Name FAXC
Gene ID 84553
Synonyms
C6orf168; Failed axon connections homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEPALLPAAQMERLAPGPLASPCPRIPRARIARRCAQRWADLGCSSGPSSGRMDQLPQK
NLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEEGEAESQW
LQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPVRDVRDVF
GVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSAYSEQAAV
LLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIELTALCDI
LGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDME
GILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLP
AFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTV
MAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVRKLNDSSS
RRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTPSTKVAHV
LRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPDAYLLDLY
RANPHGEWVLKQNPT
Target Bioclass
Transporter and channel
Family
FAX family
Subcellular location
Membrane
Function May play a role in axonal development.
Uniprot ID
Q5TGI0
Ensemble ID
ENST00000389677.6
HGNC ID
HGNC:20742

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE410 SNV: p.Q144Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C235(2.41)  LDD3410  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C235(1.02)  LDD1507  [2]
 LDCM0226  AC11 HEK-293T C235(0.94)  LDD1509  [2]
 LDCM0270  AC15 HEK-293T C235(0.95)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C235(1.05)  LDD1515  [2]
 LDCM0278  AC19 HEK-293T C235(0.86)  LDD1517  [2]
 LDCM0281  AC21 HEK-293T C235(0.97)  LDD1520  [2]
 LDCM0283  AC23 HEK-293T C235(1.00)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C235(1.02)  LDD1524  [2]
 LDCM0287  AC27 HEK-293T C235(0.90)  LDD1526  [2]
 LDCM0289  AC29 HEK-293T C235(0.92)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C235(0.91)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C235(1.00)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C235(1.00)  LDD1533  [2]
 LDCM0296  AC35 HEK-293T C235(0.98)  LDD1535  [2]
 LDCM0298  AC37 HEK-293T C235(0.90)  LDD1537  [2]
 LDCM0300  AC39 HEK-293T C235(1.07)  LDD1539  [2]
 LDCM0303  AC41 HEK-293T C235(0.97)  LDD1542  [2]
 LDCM0305  AC43 HEK-293T C235(0.98)  LDD1544  [2]
 LDCM0307  AC45 HEK-293T C235(0.83)  LDD1546  [2]
 LDCM0309  AC47 HEK-293T C235(1.00)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C235(1.05)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C235(0.82)  LDD1551  [2]
 LDCM0314  AC51 HEK-293T C235(0.94)  LDD1553  [2]
 LDCM0316  AC53 HEK-293T C235(0.92)  LDD1555  [2]
 LDCM0318  AC55 HEK-293T C235(0.93)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C235(0.98)  LDD1559  [2]
 LDCM0322  AC59 HEK-293T C235(0.91)  LDD1561  [2]
 LDCM0325  AC61 HEK-293T C235(0.91)  LDD1564  [2]
 LDCM0327  AC63 HEK-293T C235(1.05)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C235(0.97)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C235(0.90)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C235(1.05)  LDD1570  [2]
 LDCM0367  CL1 HEK-293T C235(0.93)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C235(0.93)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C235(1.01)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C235(0.99)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C235(1.07)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C235(1.07)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C235(1.00)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C235(1.13)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C235(1.16)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C235(1.02)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C235(0.92)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C235(0.95)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C235(1.15)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C235(0.87)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C235(0.78)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C235(0.96)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C235(0.94)  LDD1593  [2]
 LDCM0392  CL121 HEK-293T C235(0.98)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C235(0.95)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C235(0.92)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C235(0.83)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C235(0.90)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C235(1.01)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C235(0.84)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C235(0.89)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C235(1.28)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C235(1.26)  LDD1608  [2]
 LDCM0406  CL19 HEK-293T C235(1.02)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C235(0.90)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C235(0.99)  LDD1613  [2]
 LDCM0411  CL23 HEK-293T C235(1.04)  LDD1615  [2]
 LDCM0413  CL25 HEK-293T C235(0.82)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C235(1.00)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C235(0.99)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C235(1.09)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C235(0.98)  LDD1622  [2]
 LDCM0420  CL31 HEK-293T C235(0.89)  LDD1624  [2]
 LDCM0422  CL33 HEK-293T C235(1.05)  LDD1626  [2]
 LDCM0424  CL35 HEK-293T C235(0.66)  LDD1628  [2]
 LDCM0426  CL37 HEK-293T C235(0.95)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C235(1.05)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C235(1.03)  LDD1635  [2]
 LDCM0433  CL43 HEK-293T C235(0.95)  LDD1637  [2]
 LDCM0435  CL45 HEK-293T C235(0.92)  LDD1639  [2]
 LDCM0437  CL47 HEK-293T C235(1.08)  LDD1641  [2]
 LDCM0439  CL49 HEK-293T C235(0.82)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C235(1.04)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C235(1.02)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C235(1.19)  LDD1647  [2]
 LDCM0446  CL55 HEK-293T C235(0.98)  LDD1649  [2]
 LDCM0448  CL57 HEK-293T C235(0.91)  LDD1651  [2]
 LDCM0450  CL59 HEK-293T C235(1.02)  LDD1653  [2]
 LDCM0453  CL61 HEK-293T C235(0.93)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C235(0.86)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C235(0.87)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C235(0.98)  LDD1660  [2]
 LDCM0459  CL67 HEK-293T C235(0.96)  LDD1662  [2]
 LDCM0461  CL69 HEK-293T C235(0.86)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C235(1.08)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C235(1.05)  LDD1667  [2]
 LDCM0466  CL73 HEK-293T C235(0.84)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C235(1.00)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C235(1.00)  LDD1673  [2]
 LDCM0472  CL79 HEK-293T C235(0.94)  LDD1675  [2]
 LDCM0475  CL81 HEK-293T C235(0.94)  LDD1678  [2]
 LDCM0477  CL83 HEK-293T C235(1.11)  LDD1680  [2]
 LDCM0479  CL85 HEK-293T C235(0.81)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C235(0.88)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C235(1.01)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C235(0.97)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C235(1.07)  LDD1687  [2]
 LDCM0486  CL91 HEK-293T C235(0.94)  LDD1689  [2]
 LDCM0488  CL93 HEK-293T C235(0.94)  LDD1691  [2]
 LDCM0490  CL95 HEK-293T C235(1.34)  LDD1693  [2]
 LDCM0492  CL97 HEK-293T C235(0.96)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C235(1.02)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C235(0.96)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C235(1.06)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C235(0.89)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C235(0.97)  LDD1631  [2]
 LDCM0022  KB02 A2058 C235(2.89)  LDD2253  [1]
 LDCM0023  KB03 A2058 C235(3.60)  LDD2670  [1]
 LDCM0024  KB05 RPMI-7951 C235(2.41)  LDD3410  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402