Details of the Target

General Information of Target

Target ID LDTP17235
Target Name Probable gluconokinase (IDNK)
Gene Name IDNK
Gene ID 414328
Synonyms
C9orf103; Probable gluconokinase; EC 2.7.1.12; Gluconate kinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLWVQRKRRRKETSECPSDKDKSPESHKAKNESWIKSHFSRLSEEKLALDNNASASGNAT
QTESGSEEVSSTVHIETFTTRHGEVGSALHRESFTSRQKTSGPSVIQEIHQESGKAPSTD
EATWAAVAACTKEIDTQGRHLAHSMLQRAIAYQHSGHLESKDINQEELRALEEVEMKLQK
NFLTQRENTIAGANHTHTFYGHSHHSHHGHPSHQSHSLPNRRH
Target Bioclass
Enzyme
Family
Gluconokinase GntK/GntV family
Uniprot ID
Q5T6J7
Ensemble ID
ENST00000376419.5
HGNC ID
HGNC:31367

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.D99N .
DU145 Deletion: p.P145LfsTer23 .
KO52 Insertion: p.S168KfsTer33 .
MFE319 SNV: p.W30R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C83(1.12)  LDD3339  [1]
IA-alkyne
 Probe Info  		C105(1.26)  LDD2182  [2]
NAIA_5
 Probe Info  		N.A.  LDD2225  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C63(0.41)  LDD2227  [3]
 LDCM0572  Fragment10 Ramos C105(1.55)  LDD2189  [2]
 LDCM0574  Fragment12 Ramos C105(1.14)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C105(1.06)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C105(0.30)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C105(1.51)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C105(0.96)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C105(1.62)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C105(1.79)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C105(0.48)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C105(0.61)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C105(0.73)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C105(1.00)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C105(0.96)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C105(0.84)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C105(0.63)  LDD2184  [2]
 LDCM0614  Fragment56 Ramos C105(1.08)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C105(1.31)  LDD2186  [2]
 LDCM0022  KB02 Ramos C105(1.26)  LDD2182  [2]
 LDCM0023  KB03 Ramos C105(0.40)  LDD2183  [2]
 LDCM0024  KB05 NALM-6 C83(1.12)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264