Details of the Target

General Information of Target

Target ID LDTP17196
Target Name Zinc finger protein 506 (ZNF506)
Gene Name ZNF506
Gene ID 440515
Synonyms
Zinc finger protein 506
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKSLESVSFKDVTVDFSRDEWQQLDLAQKSLYREVMLENYFNLISVGCQVPKPEVIFSL
EQEEPCMLDGEIPSQSRPDGDIGFGPLQQRMSEEVSFQSEININLFTRDDPYSILEELWK
DDEHTRKCGENQNKPLSRVVFINKKTLANDSIFEYKDIGEIVHVNTHLVSSRKRPHNCNS
CGKNLEPIITLYNRNNATENSDKTIGDGDIFTHLNSHTEVTACECNQCGKPLHHKQALIQ
QQKIHTRESLYLFSDYVNVFSPKSHAFAHESICAEEKQHECHECEAVFTQKSQLDGSQRV
YAGICTEYEKDFSLKSNRQKTPYEGNYYKCSDYGRAFIQKSDLFRCQRIHSGEKPYEYSE
CEKNLPQNSNLNIHKKIHTGGKHFECTECGKAFTRKSTLSMHQKIHTGEKPYVCTECGKA
FIRKSHFITHERIHTGEKPYECSDCGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHK
TNLIIHQKIHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTWKSRLR
IHQKCHTGERHYECSECGKAFIQKSTLSMHQRIHRGEKPYVCTECGKAFFHKSHFITHER
IHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAFTDRSNLFTHQKIHTG
EKPYKCSDCGKAFTRKSGLHIHQQSHTGERHYECSECGKAFARKSTLIMHQRIHTGEKPY
ICNECGKSFIQKSHLNRHRRIHTGEKPYECSDCGKSFIKKSQLHEHHRIHTGEKPYICAE
CGKAFTIRSNLIKHQKIHTKQKPYKCSDLGKALNWKPQLSMPQKSDNGEVECSMPQLWCG
DSEGDQGQLSSI
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q5JVG8
Ensemble ID
ENST00000443905.6
HGNC ID
HGNC:23780

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.G116AfsTer5 .
CCK81 Deletion: p.G116AfsTer5 DBIA    Probe Info 
HCT116 SNV: p.K49E .
HCT15 SNV: p.H215Q .
HEC1 SNV: p.K289R .
Ishikawa (Heraklio) 02 ER SNV: p.K164R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C242(1.72)  LDD3311  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
HHS-465
 Probe Info  		K227(0.00); K230(0.00); Y229(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 PaTu 8988t C117(1.31); C123(1.31)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C117(1.03); C123(1.03)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C117(1.15); C123(1.15)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C117(1.01); C123(1.01)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C117(1.03); C123(1.03)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C117(1.35); C123(1.35)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C117(1.04); C123(1.04)  LDD1115  [4]
 LDCM0238  AC120 PaTu 8988t C117(0.95); C123(0.95)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C117(1.07); C123(1.07)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C117(0.83); C123(0.83)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C117(0.91); C123(0.91)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C117(1.10); C123(1.10)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C117(1.52); C123(1.52)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C117(0.99); C123(0.99)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C117(0.72); C123(0.72)  LDD1124  [4]
 LDCM0349  AC83 PaTu 8988t C117(0.90); C123(0.90)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C117(0.91); C123(0.91)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C117(0.82); C123(0.82)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C117(0.82); C123(0.82)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C117(0.86); C123(0.86)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C117(0.84); C123(0.84)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C117(0.88); C123(0.88)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C117(0.82); C123(0.82)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C117(1.04); C123(1.04)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C117(0.90); C123(0.90)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C117(0.95); C123(0.95)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C117(0.89); C123(0.89)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C117(0.94); C123(0.94)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C117(0.78); C123(0.78)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C117(0.72); C123(0.72)  LDD1243  [4]
 LDCM0420  CL31 PaTu 8988t C117(0.94); C123(0.94)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C117(1.07); C123(1.07)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C117(1.37); C123(1.37)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C117(1.23); C123(1.23)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C117(1.47); C123(1.47)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C117(1.55); C123(1.55)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C117(1.73); C123(1.73)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C117(1.24); C123(1.24)  LDD1307  [4]
 LDCM0430  CL40 PaTu 8988t C117(1.32); C123(1.32)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C117(1.38); C123(1.38)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C117(1.58); C123(1.58)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C117(1.83); C123(1.83)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C117(1.57); C123(1.57)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C117(1.19); C123(1.19)  LDD1314  [4]
 LDCM0469  CL76 PaTu 8988t C117(1.04); C123(1.04)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C117(1.01); C123(1.01)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C117(1.10); C123(1.10)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C117(1.06); C123(1.06)  LDD1351  [4]
 LDCM0474  CL80 PaTu 8988t C117(1.09); C123(1.09)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C117(1.17); C123(1.17)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C117(1.14); C123(1.14)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C117(1.28); C123(1.28)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C117(1.29); C123(1.29)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C117(0.88); C123(0.88)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C117(1.16); C123(1.16)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C117(1.34); C123(1.34)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C117(1.23); C123(1.23)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C117(1.24); C123(1.24)  LDD1362  [4]
 LDCM0485  CL90 PaTu 8988t C117(1.31); C123(1.31)  LDD1364  [4]
 LDCM0427  Fragment51 PaTu 8988t C117(1.42); C123(1.42)  LDD1306  [4]
 LDCM0022  KB02 A101D C242(1.86)  LDD2250  [1]
 LDCM0023  KB03 AU565 C242(1.50)  LDD2682  [1]
 LDCM0024  KB05 G361 C242(1.72)  LDD3311  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.