Details of the Target

General Information of Target

Target ID LDTP17141
Target Name Polyadenylate-binding protein 1-like (PABPC1L)
Gene Name PABPC1L
Synonyms
C20orf119; Polyadenylate-binding protein 1-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSAFQRLFRVLFVIETVSEYGVLIFIYGWPFLQTLAMLLIGTVSFHLWIRRNRERNSRS
GKTRCRSKRSEQSMDMGTSALSKKPWWTLPQNFHAPMVFHMEEDQEELIFGHGDTYLRCI
EVHSHTLIQLESWFTATGQTRVTVVGPHRARQWLLHMFCCVGSQDSYHHARGLEMLERVR
SQPLTNDDLVTSISVPPYTGDLSLAPRISGTVCLSVPQPSPYQVIGCSGFHLSSLYP
Target Bioclass
Other
Family
Polyadenylate-binding protein type-1 family
Uniprot ID
Q4VXU2
Ensemble ID
ENST00000255136.8
HGNC ID
HGNC:15797

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		D165(10.00)  LDD2208  [1]
DBIA
 Probe Info  		C339(1.40)  LDD3310  [2]
AHL-Pu-1
 Probe Info  		C339(2.44)  LDD0169  [3]
HHS-475
 Probe Info  		Y297(0.70); Y291(0.78)  LDD0264  [4]
HHS-465
 Probe Info  		Y291(8.36); Y297(8.02)  LDD2237  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C339(2.44)  LDD0169  [3]
 LDCM0116  HHS-0101 DM93 Y297(0.70); Y291(0.78)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y297(0.62); Y291(0.67)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y291(0.73); Y297(0.80)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y297(0.72); Y291(0.77)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y297(0.59); Y291(0.81)  LDD0268  [4]
 LDCM0022  KB02 22RV1 C339(1.44)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C339(1.57)  LDD2660  [2]
 LDCM0024  KB05 COLO792 C339(1.40)  LDD3310  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.