Details of the Target

General Information of Target

Target ID LDTP17052
Target Name Myeloid leukemia factor 2 (MLF2)
Gene Name MLF2
Gene ID 8079
Synonyms
Myeloid leukemia factor 2; Myelodysplasia-myeloid leukemia factor 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPGNDTQISEFLLLGFSQEPGLQPFLFGLFLSMYLVTVLGNLLIILATISDSHLHTPMY
FFLSNLSFADICVTSTTIPKMLMNIQTQNKVITYIACLMQMYFFILFAGFENFLLSVMAY
DRFVAICHPLHYMVIMNPHLCGLLVLASWTMSALYSLLQILMVVRLSFCTALEIPHFFCE
LNQVIQLACSDSFLNHMVIYFTVALLGGGPLTGILYSYSKIISSIHAISSAQGKYKAFST
CASHLSVVSLFYGAILGVYLSSAATRNSHSSATASVMYTVVTPMLNPFIYSLRNKDIKRA
LGIHLLWGTMKGQFFKKCP
Target Bioclass
Other
Family
MLF family
Subcellular location
Cytoplasm
Uniprot ID
Q15773
Ensemble ID
ENST00000203630.10
HGNC ID
HGNC:7126
ChEMBL ID
CHEMBL4295830

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.35  LDD0402  [1]
Jackson_1
 Probe Info  		20.00  LDD0122  [2]
Probe 1
 Probe Info  		Y121(6.68)  LDD3495  [3]
Acrolein
 Probe Info  		N.A.  LDD0223  [4]
IA-alkyne
 Probe Info  		C158(0.00); C463(0.00)  LDD0161  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myeloid leukemia factor 1 (MLF1) MLF family P58340
Heat shock protein beta-8 (HSPB8) Small heat shock protein (HSP20) family Q9UJY1
BAG family molecular chaperone regulator 1 (BAG1) . Q99933
BAG family molecular chaperone regulator 2 (BAG2) . O95816
BAG family molecular chaperone regulator 3 (BAG3) . O95817
DnaJ homolog subfamily B member 6 (DNAJB6) . O75190

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.