Details of the Target

General Information of Target

Target ID LDTP17000
Target Name Selenoprotein W (SELENOW)
Gene Name SELENOW
Gene ID 6415
Synonyms
SELW; SEPW1; Selenoprotein W; SelW
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASE
VYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMT
KMGYIPGKGLGKNEDGIKVPVEAKINQEREGIGYPF
Target Bioclass
Other
Family
SelWTH family, Selenoprotein W subfamily
Subcellular location
Cytoplasm
Function Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.
Uniprot ID
P63302
Ensemble ID
ENST00000593892.5
HGNC ID
HGNC:10752

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C37(1.21)  LDD1492  [1]
IA-alkyne
 Probe Info  		C1432(0.00); C3347(0.00); C1312(0.00); C2248(0.00)  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C37(1.12)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C37(0.94)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C37(0.91)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C37(1.04)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C37(0.99)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C37(1.13)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C37(0.96)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C37(1.05)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C37(1.09)  LDD1607  [1]
 LDCM0416  CL28 HEK-293T C37(1.09)  LDD1620  [1]
 LDCM0429  CL4 HEK-293T C37(1.26)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C37(1.04)  LDD1634  [1]
 LDCM0443  CL52 HEK-293T C37(0.97)  LDD1646  [1]
 LDCM0456  CL64 HEK-293T C37(0.80)  LDD1659  [1]
 LDCM0469  CL76 HEK-293T C37(1.05)  LDD1672  [1]
 LDCM0482  CL88 HEK-293T C37(1.10)  LDD1685  [1]
 LDCM0022  KB02 HEK-293T C37(1.21)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C37(1.22)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C37(1.04)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060