Details of the Target
General Information of Target
| Target ID | LDTP16913 | |||||
|---|---|---|---|---|---|---|
| Target Name | SLIT-ROBO Rho GTPase-activating protein 2B (SRGAP2B) | |||||
| Gene Name | SRGAP2B | |||||
| Synonyms |
SRGAP2P2; SLIT-ROBO Rho GTPase-activating protein 2B; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2 |
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| 3D Structure | ||||||
| Sequence |
MENLPFPLKLLSASSLNTPSSTPWVLDIFLTLVFALGLFFLLLPYFSYLRCDNPPSPSPR
KRKRHLVSQRHLVSQCPTGRRGRPRGRMKNHSLRACRECPRGLEETWDLLSQLQSLLGPH LEKGDFGQLSGPDPPGEVGKRTPDGASRSSHEPMEDAAPIVSPLASPDPRTKHPQDLAST PPPGPMTTSVSSLSASQPPEPSLLLERPSPEPPALFPHPPHTPDPLACSPPPPKGFTPPP LRDSTLLTPSHCDSVALPLDTVPQSLSPREDLAASVPAISGLGGSNSQVSALSWSQETTK TWCIFNSSVQQDHLSRQRDTTMSPLLFQAQPLSHLGPESQPFISSTPQFRPTPMAQAEAQ AHLQSSFPVLSPAFLSPMKNTGVACPASQNKVQALSLPETQHPERPLLRKQLEGGLALPS RVQKSQDVFSVSTPNLPQERLTSILPENFPVSPELWRQLEQYMGQRGRIQESLDLMQLQD ELPGTSQAKGKPRPWQSSTSTGESSKEAQTVKFQLERDPCPHLGQILGETPQNLSRGMES FPGKVLGATSEESERNLRKPLRSDSGSDLLRRTERNHIENILKAHMGRKLGQTNEGLIPV SVRRSWLAVNQAFPVSNTHVKTSNLAAPKSRKACVNTAQVLSFLELCTQQVLEAHIVRFW AKHRWGLPLRVLKPIQCFQLEKVSSLSLIQLAGPSSDTCESGAGSKVEVATLLGEPPMAS LRKQVLTKPSVHMPERLQASSPACKQFQRAPRGIPSSNDHGSLKAPTAGQEGRWPSKPLT YSLKGSTQQSRSLGAQSSRAGETREAVPQPTVPLGTCMRANLQATSEDVRGFKAPGASKS SLLPRMSVSQDPRKLCLMEEAVSEFEPGMATKSETQPQVSAAVVLLPDGQASVVPHASEN LASQVPQGHLQSTPTGNMQASQELCDLMSARRSNMGHKEPRNPNCQGSCKSQSPMFPPTH KRENSRKPNLEKHEEMFQGLRTPQLTPGRKTEDTRQNEGVQLLPSKKQPPSISHFGENIK QFFETIFSKKERKPAPVTAESQKTVKNRSCVYGSSAEAERLMTAVGQIPEENMSLCHARH ASKVNQQRQQFQAPVCGFPCNHRHPFYSDHSRMLSYAASSQQATLKNQSRPNRDRQIRDQ QPLKSVRCNNEQWGLRHPQLLLPKKAVSPVSPPQHRPKTPSASSHHHH |
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| Target Bioclass |
Other
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| Function |
May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2. In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
TH211 Probe Info |
 |
Y170(20.00) | LDD0260 | [1] | |
|
DBIA Probe Info |
 |
C98(4.80) | LDD3331 | [2] | |
|
HHS-475 Probe Info |
 |
Y170(1.01) | LDD0264 | [3] | |
|
HHS-465 Probe Info |
 |
Y170(10.00) | LDD2237 | [4] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
VE-P Probe Info |
 |
N.A. | LDD0396 | [5] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0116 | HHS-0101 | DM93 | Y170(1.01) | LDD0264 | [3] |
| LDCM0117 | HHS-0201 | DM93 | Y170(0.68) | LDD0265 | [3] |
| LDCM0118 | HHS-0301 | DM93 | Y170(0.64) | LDD0266 | [3] |
| LDCM0119 | HHS-0401 | DM93 | Y170(0.72) | LDD0267 | [3] |
| LDCM0120 | HHS-0701 | DM93 | Y170(1.65) | LDD0268 | [3] |
| LDCM0022 | KB02 | 22RV1 | C98(3.26) | LDD2243 | [2] |
| LDCM0023 | KB03 | 22RV1 | C98(4.68) | LDD2660 | [2] |
| LDCM0024 | KB05 | MKN-1 | C98(4.80) | LDD3331 | [2] |
References