General Information of Target

Target ID LDTP16909
Target Name RANBP2-like and GRIP domain-containing protein 1 (RGPD1)
Gene Name RGPD1
Gene ID 400966
Synonyms
RANBP2L6; RGP1; RANBP2-like and GRIP domain-containing protein 1; Ran-binding protein 2-like 6; RanBP2-like 6; RanBP2L6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFSGRARPCIIPENEEIPRAALNTVHEANGTEDERAVSKLQRRHSDVKVYKEFCDFYAK
FNMANALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQCFQQFPEGLFYEERT
Target Bioclass
Other
Uniprot ID
P0DJD0
HGNC ID
HGNC:32414

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C82(3.22); C101(1.98); C2381(3.08); C206(2.69)  LDD3311  [1]
AHL-Pu-1
 Probe Info 
C528(2.08); C211(2.15)  LDD0169  [2]
IA-alkyne
 Probe Info 
C340(0.00); C528(0.00); C1093(0.00); C1390(0.00)  LDD0166  [3]
NAIA_5
 Probe Info 
N.A.  LDD2224  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C528(2.08); C211(2.15)  LDD0169  [2]
 LDCM0022  KB02 22RV1 C349(2.12); C82(2.07); C101(1.20); C2381(1.92)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C349(2.49); C82(4.12); C101(1.42); C2381(2.93)  LDD2660  [1]
 LDCM0024  KB05 G361 C82(3.22); C101(1.98); C2381(3.08); C206(2.69)  LDD3311  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264