Details of the Target

General Information of Target

Target ID LDTP16820
Target Name Zinc finger protein 737 (ZNF737)
Gene Name ZNF737
Gene ID 100129842
Synonyms
ZNF102; Zinc finger protein 737; Zinc finger protein 102
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAFLSAGLGILAPSETYPLPTTSSGWEPRLGSPFPSGPCTSSTGAQAVAEPTGQGPKNP
RVSRVTVQLEMKPLWEEFNQLGTEMIVTKAGRRMFPPFQVKILGMDSLADYALLMDFIPL
DDKRYRYAFHSSAWLVAGKADPATPGRVHFHPDSPAKGAQWMRQIVSFDKLKLTNNLLDD
NGHIILNSMHRYQPRFHVVFVDPRKDSERYAQENFKSFIFTETQFTAVTAYQNHRITQLK
IASNPFAKGFRESDLDSWPVAPRPLLSVPARSHSSLSPCVLKGATDREKDPNKASASTSK
TPAWLHHQLLPPPEVLLAPATYRPVTYQSLYSGAPSHLGIPRTRPAPYPLPNIRADRDQG
GLPLPAGLGLLSPTVVCLGPGQDSQ
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
O75373
Ensemble ID
ENST00000427401.9
HGNC ID
HGNC:32468

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C436(1.05)  LDD3421  [1]
NAIA_5
 Probe Info  		C436(1.95)  LDD2227  [2]
IA-alkyne
 Probe Info  		C346(5.46)  LDD0315  [3]
HHS-465
 Probe Info  		K283(0.00); K286(0.00); Y285(0.00)  LDD2240  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0320  AC57 PaTu 8988t C117(1.23); C123(1.23)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C117(1.35); C123(1.35)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C117(1.32); C123(1.32)  LDD1201  [5]
 LDCM0324  AC60 PaTu 8988t C117(1.46); C123(1.46)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C117(1.25); C123(1.25)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C117(1.11); C123(1.11)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C117(1.11); C123(1.11)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C117(1.04); C123(1.04)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C117(1.11); C123(1.11)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C117(1.38); C123(1.38)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C117(1.10); C123(1.10)  LDD1210  [5]
 LDCM0332  AC68 PaTu 8988t C117(0.89); C123(0.89)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C117(0.91); C123(0.91)  LDD1212  [5]
 LDCM0335  AC70 PaTu 8988t C117(0.98); C123(0.98)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C117(0.93); C123(0.93)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C117(0.65); C123(0.65)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C117(0.76); C123(0.76)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C117(0.78); C123(0.78)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C117(0.90); C123(0.90)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C117(0.89); C123(0.89)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C117(0.98); C123(0.98)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C117(0.75); C123(0.75)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C117(0.84); C123(0.84)  LDD1223  [5]
 LDCM0346  AC80 PaTu 8988t C117(0.77); C123(0.77)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C117(0.81); C123(0.81)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C117(0.72); C123(0.72)  LDD1227  [5]
 LDCM0349  AC83 PaTu 8988t C117(0.87); C123(0.87)  LDD1228  [5]
 LDCM0350  AC84 PaTu 8988t C117(0.91); C123(0.91)  LDD1229  [5]
 LDCM0351  AC85 PaTu 8988t C117(0.87); C123(0.87)  LDD1230  [5]
 LDCM0352  AC86 PaTu 8988t C117(0.81); C123(0.81)  LDD1231  [5]
 LDCM0353  AC87 PaTu 8988t C117(0.87); C123(0.87)  LDD1232  [5]
 LDCM0354  AC88 PaTu 8988t C117(0.86); C123(0.86)  LDD1233  [5]
 LDCM0355  AC89 PaTu 8988t C117(0.82); C123(0.82)  LDD1234  [5]
 LDCM0357  AC90 PaTu 8988t C117(0.84); C123(0.84)  LDD1236  [5]
 LDCM0358  AC91 PaTu 8988t C117(0.91); C123(0.91)  LDD1237  [5]
 LDCM0359  AC92 PaTu 8988t C117(0.84); C123(0.84)  LDD1238  [5]
 LDCM0360  AC93 PaTu 8988t C117(0.67); C123(0.67)  LDD1239  [5]
 LDCM0361  AC94 PaTu 8988t C117(0.83); C123(0.83)  LDD1240  [5]
 LDCM0362  AC95 PaTu 8988t C117(0.85); C123(0.85)  LDD1241  [5]
 LDCM0363  AC96 PaTu 8988t C117(0.77); C123(0.77)  LDD1242  [5]
 LDCM0364  AC97 PaTu 8988t C117(0.77); C123(0.77)  LDD1243  [5]
 LDCM0632  CL-Sc Hep-G2 C436(1.95)  LDD2227  [2]
 LDCM0367  CL1 PaTu 8988t C117(1.25); C123(1.25)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C117(1.71); C123(1.71)  LDD1247  [5]
 LDCM0379  CL11 PaTu 8988t C117(1.07); C123(1.07)  LDD1258  [5]
 LDCM0390  CL12 PaTu 8988t C117(1.13); C123(1.13)  LDD1269  [5]
 LDCM0396  CL125 PaTu 8988t C117(1.30); C123(1.30)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C117(1.13); C123(1.13)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C117(1.11); C123(1.11)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C117(1.09); C123(1.09)  LDD1278  [5]
 LDCM0400  CL13 PaTu 8988t C117(1.60); C123(1.60)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C117(1.45); C123(1.45)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C117(1.43); C123(1.43)  LDD1281  [5]
 LDCM0403  CL16 PaTu 8988t C117(1.23); C123(1.23)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C117(1.08); C123(1.08)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C117(1.32); C123(1.32)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C117(1.02); C123(1.02)  LDD1285  [5]
 LDCM0407  CL2 PaTu 8988t C117(1.22); C123(1.22)  LDD1286  [5]
 LDCM0408  CL20 PaTu 8988t C117(1.01); C123(1.01)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C117(1.17); C123(1.17)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C117(1.12); C123(1.12)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C117(1.21); C123(1.21)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C117(1.09); C123(1.09)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C117(1.36); C123(1.36)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C117(1.18); C123(1.18)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C117(1.34); C123(1.34)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C117(1.10); C123(1.10)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C117(1.01); C123(1.01)  LDD1296  [5]
 LDCM0418  CL3 PaTu 8988t C117(1.45); C123(1.45)  LDD1297  [5]
 LDCM0419  CL30 PaTu 8988t C117(1.07); C123(1.07)  LDD1298  [5]
 LDCM0429  CL4 PaTu 8988t C117(1.15); C123(1.15)  LDD1308  [5]
 LDCM0440  CL5 PaTu 8988t C117(1.47); C123(1.47)  LDD1319  [5]
 LDCM0451  CL6 PaTu 8988t C117(1.15); C123(1.15)  LDD1330  [5]
 LDCM0462  CL7 PaTu 8988t C117(1.58); C123(1.58)  LDD1341  [5]
 LDCM0473  CL8 PaTu 8988t C117(2.01); C123(2.01)  LDD1352  [5]
 LDCM0484  CL9 PaTu 8988t C117(0.99); C123(0.99)  LDD1363  [5]
 LDCM0022  KB02 22RV1 C436(4.26)  LDD2243  [1]
 LDCM0023  KB03 Jurkat C346(5.46)  LDD0315  [3]
 LDCM0024  KB05 SiSo C436(1.05)  LDD3421  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.