General Information of Target

Target ID LDTP16789
Target Name TPR and ankyrin repeat-containing protein 1 (TRANK1)
Gene Name TRANK1
Gene ID 9881
Synonyms
KIAA0342; LBA1; TPR and ankyrin repeat-containing protein 1; Lupus brain antigen 1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSASTSSHRPIKGILKNKSSSGSSVATSGQQSGGTIQDVKRKKSQKWDESSILAAHRATY
RDYDLMKANEPGTSYMSVQDNGEDSVRDVEGEDSVRGVEGKEATDASDHSCEVDEQESSE
AYMRKILLHKQEKKRQFEMRRRLHYNEELNIKLARQLMWKELQSEDNENEETPQGTNEEK
TAAEESEEAPLTGGLQTQSCDP
Target Bioclass
Other
Uniprot ID
O15050
Ensemble ID
ENST00000429976.5
HGNC ID
HGNC:29011

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C646(3.81)  LDD3310  [1]
IA-alkyne
 Probe Info 
C338(0.00); C241(0.00); C542(0.00); C162(0.00)  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0575  Fragment13 Ramos C41(1.17)  LDD2192  [3]
 LDCM0578  Fragment27 Ramos C41(0.61)  LDD2197  [3]
 LDCM0596  Fragment38 Ramos C41(0.20)  LDD2203  [3]
 LDCM0022  KB02 T cell C1319(20.00); C882(6.58)  LDD1703  [4]
 LDCM0023  KB03 A3-KAW C646(4.56)  LDD2674  [1]
 LDCM0024  KB05 COLO792 C646(3.81)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.