Details of the Target

General Information of Target

Target ID LDTP16787
Target Name Regulator of G-protein signaling 13 (RGS13)
Gene Name RGS13
Gene ID 6003
Synonyms
Regulator of G-protein signaling 13; RGS13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRSKADVERYVASVLGLTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDP
KAHRFLGLLYELEENTEKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWVER
AAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVELYRSTKR
LKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYA
NLMLLTLSTRDVQENRELLESFDSALQSAKSSLGGNDELSATFLEMKGHFYMYAGSLLLK
MGQHGNNVQWRALSELAALCYLIAFQVPRPKIKLREGKAGQNLLEMMACDRLSQSGHMLL
SLSRGKQDFLKEVVETFANKIGQSALYDALFSSQSPKDTSFLGSDDIGKIDVQEPELEDL
ARYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHRLPHETSRLETNAPESI
CILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPFPVCKQLCTERQKSWWDAVCTLI
HRKAVPGNLAKLRLLVQHEINTLRAQEKHGLQPALLVHWAKYLQKTGSGLNSFYGQLEYI
GRSVHYWKKVLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAV
NGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECRNYLTKTRDYLIK
IIDDGDSNLSVVKKLPVPLESVKQMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTP
SPTKYSLSPSKSYKYSPETPPRWTEDRNSLLNMICQQVEAIKKEMQELKLNSSKSASRHR
WPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
SSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKREKPLENDTGLQAQDIRGRKKGRGV
IFGQTSSTFTFADVAKSTSGEGFQFGKKDLNFKGFSGAGEKLFSSRYGKMANKANTSGDF
EKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEGEKVLYSQGVKLFRFDAEVRQWKERG
LGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWSASDFSDGD
AKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSG
LKDFKTFLTNDQTKVTEEENKGSGTGVAGASDTTIKPNAENTGPTLEWDNYDLREDALDD
SVSSSSVHASPLASSPVRKNLFRFDESTTGSNFSFKSALSLSKSPAKLNQSGTSVGTDEE
SVVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAEIYRYDKDVGQWKERGIGD
IKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKV
EHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEEIT
RERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSSEKSKPFAFG
NSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNL
SASFPTEESSINYTFKTPEKEPPLWHAEFTKEELVQKLRSTTKSADHLNGLLREIEATNA
VLMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQ
LSPEEKGKLAAVAQDEEENPSRSSG
Target Bioclass
Other
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha.
Uniprot ID
O14921
Ensemble ID
ENST00000391995.7
HGNC ID
HGNC:9995

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C34(0.00); C48(0.00); C908(0.00)  LDD0161  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C120(1.72)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C120(2.12)  LDD2189  [2]
 LDCM0574  Fragment12 Ramos C120(3.02)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C120(0.90)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C120(1.33)  LDD2193  [2]
 LDCM0580  Fragment21 Ramos C120(1.26)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C120(0.83)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C120(0.85)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C120(0.72)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C120(1.11)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C120(1.02)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C120(2.52)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C120(1.14)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C120(0.68)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C120(2.56)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C120(1.47)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C120(1.00)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C120(2.62)  LDD2186  [2]
 LDCM0022  KB02 Ramos C120(3.78)  LDD2182  [2]
 LDCM0023  KB03 Ramos C120(3.22)  LDD2183  [2]
 LDCM0024  KB05 Ramos C120(6.17)  LDD2185  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein L6 (APOL6) Apolipoprotein L family Q9BWW8

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578