General Information of Target

Target ID LDTP16786
Target Name RANBP2-like and GRIP domain-containing protein 8 (RGPD8)
Gene Name RGPD8
Gene ID 727851
Synonyms
RANBP2ALPHA; RANBP2L1; RANBP2L3; RANBP2-like and GRIP domain-containing protein 8; Ran-binding protein 2-like 3; RanBP2-like 3; RanBP2L3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDKPGMAEIEKFDKSKLKKTETQEKNPLSSKETIEQERQAGES
Target Bioclass
Other
Uniprot ID
O14715
Ensemble ID
ENST00000302558.8
HGNC ID
HGNC:9849

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C815(1.82)  LDD3403  [1]
AHL-Pu-1
 Probe Info 
C50(2.31)  LDD0168  [2]
IA-alkyne
 Probe Info 
C449(0.00); C528(0.00); C81(0.00); C134(0.00)  LDD0161  [3]
IPM
 Probe Info 
C815(0.00); C707(0.00)  LDD2156  [4]
Phosphinate-6
 Probe Info 
C188(0.00); C1601(0.00); C105(0.00); C1488(0.00)  LDD0018  [5]
NAIA_5
 Probe Info 
N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C50(2.31)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C537(2.08); C220(2.15); C50(2.22)  LDD0169  [2]
 LDCM0022  KB02 697 C815(1.42)  LDD2245  [1]
 LDCM0023  KB03 697 C815(2.33)  LDD2662  [1]
 LDCM0024  KB05 Reh C815(1.82)  LDD3403  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264