Details of the Target

General Information of Target

Target ID LDTP16782
Target Name Ubiquitin domain-containing protein UBFD1 (UBFD1)
Gene Name UBFD1
Gene ID 56061
Synonyms
UBPH; Ubiquitin domain-containing protein UBFD1; Ubiquitin-binding protein homolog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN
RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN
LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN
PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP
SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS
QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH
GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL
LFFFLTSF
Target Bioclass
Other
Function May play a role as NF-kappa-B regulator.
Uniprot ID
O14562
Ensemble ID
ENST00000395878.8
HGNC ID
HGNC:30565

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K224(10.00); K96(5.65)  LDD0277  [2]
DBIA
 Probe Info  		C185(1.64)  LDD3340  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C33(1.00)  LDD1507  [10]
 LDCM0276  AC17 HEK-293T C33(0.97)  LDD1515  [10]
 LDCM0285  AC25 HEK-293T C33(0.92)  LDD1524  [10]
 LDCM0294  AC33 HEK-293T C33(0.97)  LDD1533  [10]
 LDCM0303  AC41 HEK-293T C33(0.98)  LDD1542  [10]
 LDCM0311  AC49 HEK-293T C33(0.92)  LDD1550  [10]
 LDCM0320  AC57 HEK-293T C33(0.92)  LDD1559  [10]
 LDCM0356  AKOS034007680 HEK-293T C33(1.00)  LDD1570  [10]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0632  CL-Sc Hep-G2 C185(1.19); C185(0.79)  LDD2227  [9]
 LDCM0372  CL103 HEK-293T C33(0.94)  LDD1576  [10]
 LDCM0376  CL107 HEK-293T C33(0.92)  LDD1580  [10]
 LDCM0381  CL111 HEK-293T C33(0.95)  LDD1585  [10]
 LDCM0385  CL115 HEK-293T C33(0.91)  LDD1589  [10]
 LDCM0389  CL119 HEK-293T C33(1.03)  LDD1593  [10]
 LDCM0394  CL123 HEK-293T C33(0.84)  LDD1598  [10]
 LDCM0398  CL127 HEK-293T C33(0.91)  LDD1602  [10]
 LDCM0402  CL15 HEK-293T C33(0.96)  LDD1606  [10]
 LDCM0404  CL17 HEK-293T C33(0.82)  LDD1608  [10]
 LDCM0415  CL27 HEK-293T C33(0.97)  LDD1619  [10]
 LDCM0417  CL29 HEK-293T C33(1.03)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C33(0.93)  LDD1622  [10]
 LDCM0428  CL39 HEK-293T C33(1.05)  LDD1632  [10]
 LDCM0431  CL41 HEK-293T C33(1.08)  LDD1635  [10]
 LDCM0440  CL5 HEK-293T C33(1.01)  LDD1644  [10]
 LDCM0444  CL53 HEK-293T C33(0.87)  LDD1647  [10]
 LDCM0455  CL63 HEK-293T C33(0.90)  LDD1658  [10]
 LDCM0457  CL65 HEK-293T C33(1.02)  LDD1660  [10]
 LDCM0470  CL77 HEK-293T C33(0.93)  LDD1673  [10]
 LDCM0481  CL87 HEK-293T C33(0.85)  LDD1684  [10]
 LDCM0483  CL89 HEK-293T C33(0.88)  LDD1686  [10]
 LDCM0494  CL99 HEK-293T C33(0.82)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C33(0.95)  LDD1698  [10]
 LDCM0625  F8 Ramos C185(2.68)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C185(0.62)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C185(2.92)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C185(0.56)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C185(1.05)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C185(0.42)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C185(0.38)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C185(0.64)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C185(0.81)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C185(1.04)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C185(0.60)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C185(0.79)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C185(0.93)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C185(0.91)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C33(0.88)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C185(1.86)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C185(0.70)  LDD2184  [11]
 LDCM0610  Fragment52 Ramos C185(1.29)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C185(0.72)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C185(0.47)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C185(0.36)  LDD2188  [11]
 LDCM0022  KB02 Ramos C185(0.62)  LDD2182  [11]
 LDCM0023  KB03 Ramos C185(0.48)  LDD2183  [11]
 LDCM0024  KB05 NB1 C185(1.64)  LDD3340  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578