General Information of Target

Target ID LDTP16765
Target Name Peptidyl-prolyl cis-trans isomerase A-like 4D (PPIAL4D)
Gene Name PPIAL4D
Gene ID 645142
Synonyms
Peptidyl-prolyl cis-trans isomerase A-like 4D; PPIase A-like 4D; EC 5.2.1.8
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQ
LLYITAFFFAGYYLVKREDYLYAVRDREMFGYMKLHPEDFPEEDVYCCGAERRG
Target Bioclass
Enzyme
Family
Cyclophilin-type PPIase family, PPIase A subfamily
Subcellular location
Cytoplasm
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Uniprot ID
F5H284
Ensemble ID
ENST00000544708.3
HGNC ID
HGNC:33998

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info 
E120(1.12)  LDD2208  [1]
AHL-Pu-1
 Probe Info 
C52(3.10)  LDD0168  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C52(3.10)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C52(3.02)  LDD0169  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625