Details of the Target

General Information of Target

Target ID LDTP16731
Target Name Protein phosphatase 1 regulatory subunit 3G (PPP1R3G)
Gene Name PPP1R3G
Gene ID 648791
Synonyms
Protein phosphatase 1 regulatory subunit 3G
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIENSSWSMTFEERENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNK
ELLLTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQICSQLST
RLEKQQAASKEELEVVKGKMMACKHCSDIFSKEGALKLAATGREDQGIETDDEKDSLKKQ
LREMELELAQTKLQLVEAKCKIQELEHQRGALMNEIQAAKNSWFSKTLNSIKTATGTQPL
QPAPVTQPPKEST
Target Bioclass
Other
Function
Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits.
Uniprot ID
B7ZBB8
Ensemble ID
ENST00000405617.4
HGNC ID
HGNC:14945

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C225(1.48)  LDD3319  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C225(0.95)  LDD1573  [2]
 LDCM0373  CL104 HEK-293T C225(1.20)  LDD1577  [2]
 LDCM0377  CL108 HEK-293T C225(0.76)  LDD1581  [2]
 LDCM0382  CL112 HEK-293T C225(1.12)  LDD1586  [2]
 LDCM0386  CL116 HEK-293T C225(0.92)  LDD1590  [2]
 LDCM0391  CL120 HEK-293T C225(1.18)  LDD1595  [2]
 LDCM0395  CL124 HEK-293T C225(1.08)  LDD1599  [2]
 LDCM0399  CL128 HEK-293T C225(0.96)  LDD1603  [2]
 LDCM0403  CL16 HEK-293T C225(1.11)  LDD1607  [2]
 LDCM0416  CL28 HEK-293T C225(0.92)  LDD1620  [2]
 LDCM0429  CL4 HEK-293T C225(0.96)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C225(1.09)  LDD1634  [2]
 LDCM0443  CL52 HEK-293T C225(1.17)  LDD1646  [2]
 LDCM0456  CL64 HEK-293T C225(0.92)  LDD1659  [2]
 LDCM0469  CL76 HEK-293T C225(1.01)  LDD1672  [2]
 LDCM0482  CL88 HEK-293T C225(1.10)  LDD1685  [2]
 LDCM0022  KB02 786-O C225(1.39)  LDD2247  [1]
 LDCM0023  KB03 42-MG-BA C225(2.04)  LDD2661  [1]
 LDCM0024  KB05 MEWO C225(1.48)  LDD3319  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402