Details of the Target

General Information of Target

Target ID LDTP16655
Target Name RanBP2-like and GRIP domain-containing protein 3 (RGPD3)
Gene Name RGPD3
Gene ID 653489
Synonyms
RGP3; RanBP2-like and GRIP domain-containing protein 3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSTFPVLAEDIPLRERHVKGRVDPHFRAPKMEMFQRLLLLLLLSMGGTWASKEPLRPRCR
PINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLP
GCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPS
PSRLPGP
Target Bioclass
Other
Uniprot ID
A6NKT7
Ensemble ID
ENST00000409886.4
HGNC ID
HGNC:32416

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.54  LDD0402  [1]
IPM
 Probe Info  		C141(0.00); C349(0.00); C1109(0.00); C1167(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y83(16.53); Y786(30.03); Y1008(6.99); Y1028(53.59)  LDD3495  [3]
DBIA
 Probe Info  		C84(2.44)  LDD3323  [4]
AHL-Pu-1
 Probe Info  		C537(2.08); C220(2.15)  LDD0169  [5]
HHS-475
 Probe Info  		Y1008(5.85)  LDD0264  [6]
NAIA_5
 Probe Info  		C320(0.00); C481(0.00); C537(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C537(2.08); C220(2.15)  LDD0169  [5]
 LDCM0116  HHS-0101 DM93 Y1008(5.85)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y1008(3.57)  LDD0265  [6]
 LDCM0119  HHS-0401 DM93 Y1008(3.89)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y1008(0.92)  LDD0268  [6]
 LDCM0022  KB02 22RV1 C525(4.09)  LDD2243  [4]
 LDCM0023  KB03 22RV1 C525(5.12)  LDD2660  [4]
 LDCM0024  KB05 SKMEL24 C84(2.44)  LDD3323  [4]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264