Details of the Target

General Information of Target

Target ID LDTP16461
Target Name Peptidyl-prolyl cis-trans isomerase A-like 4C (PPIAL4C)
Gene Name PPIAL4C
Gene ID 653598
Synonyms
Peptidyl-prolyl cis-trans isomerase A-like 4C; PPIase A-like 4C; EC 5.2.1.8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSSLDFLILILMFGGTSSNSVKQTGQITVSEGASVTMNCTYTSTGYPTLFWYVEYPSKP
LQLLQRETMENSKNFGGGNIKDKNSPIVKYSVQVSDSAVYYCLLG
Target Bioclass
Enzyme
Family
Cyclophilin-type PPIase family, PPIase A subfamily
Subcellular location
Cytoplasm
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Uniprot ID
A0A0B4J2A2
Ensemble ID
ENST00000585245.3
HGNC ID
HGNC:33995

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E120(1.12)  LDD2208  [1]
AHL-Pu-1
 Probe Info  		C52(3.10)  LDD0168  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
1c-yne
 Probe Info  		N.A.  LDD0228  [4]
Acrolein
 Probe Info  		C62(0.00); C52(0.00)  LDD0217  [5]
Cinnamaldehyde
 Probe Info  		C62(0.00); C52(0.00)  LDD0220  [5]
Crotonaldehyde
 Probe Info  		C62(0.00); C52(0.00); H54(0.00)  LDD0219  [5]
Methacrolein
 Probe Info  		C62(0.00); C52(0.00)  LDD0218  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C52(3.10)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C52(3.02)  LDD0169  [2]
 LDCM0108  Chloroacetamide HeLa C62(0.00); C52(0.00)  LDD0222  [5]
 LDCM0107  IAA HeLa C62(0.00); C52(0.00); H54(0.00)  LDD0221  [5]
 LDCM0109  NEM HeLa C62(0.00); C52(0.00); H54(0.00)  LDD0223  [5]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264