Details of the Target

General Information of Target

Target ID LDTP16398
Target Name Cytochrome b-c1 complex subunit 6-like, mitochondrial (UQCRHL)
Gene Name UQCRHL
Gene ID 440567
Synonyms
Cytochrome b-c1 complex subunit 6-like, mitochondrial
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDQAYKGMPMNIRGPMWSVLLNTEEM
KLKNPGRYQIMKEKGKKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEY
NPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE
HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI
TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPP
AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA
VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV
RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHL
ESSQFPPGF
Target Bioclass
Enzyme
Family
UQCRH/QCR6 family
Subcellular location
Mitochondrion inner membrane
Function
May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
Uniprot ID
A0A096LP55
Ensemble ID
ENST00000483273.2
HGNC ID
HGNC:51714

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C37(1.19)  LDD3313  [1]
AHL-Pu-1
 Probe Info  		C81(2.55)  LDD0170  [2]
IA-alkyne
 Probe Info  		C37(0.00); C81(0.00)  LDD2241  [3]
Acrolein
 Probe Info  		C37(0.00); C81(0.00)  LDD0217  [4]
Crotonaldehyde
 Probe Info  		C37(0.00); C81(0.00); H80(0.00)  LDD0219  [4]
Methacrolein
 Probe Info  		C81(0.00); C37(0.00); H84(0.00)  LDD0218  [4]
NAIA_5
 Probe Info  		C81(0.00); C37(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C81(2.55)  LDD0170  [2]
 LDCM0108  Chloroacetamide HeLa C37(0.00); C81(0.00); H80(0.00)  LDD0222  [4]
 LDCM0107  IAA HeLa C37(0.00); H80(0.00); C81(0.00)  LDD0221  [4]
 LDCM0022  KB02 HEK-293T C81(0.99); C37(0.97)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C81(1.10); C37(1.04)  LDD1497  [6]
 LDCM0024  KB05 Hs 936.T C37(1.19)  LDD3313  [1]
 LDCM0109  NEM HeLa C37(0.00); C81(0.00); H80(0.00)  LDD0223  [4]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402