Details of the Target

General Information of Target

Target ID LDTP16381
Target Name Peptidyl-prolyl cis-trans isomerase A-like 4E (PPIAL4E)
Gene Name PPIAL4E
Gene ID 728945
Synonyms
Peptidyl-prolyl cis-trans isomerase A-like 4E; PPIase A-like 4E; EC 5.2.1.8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSASCSGLVILLIFRRTSGDSVTQTEGPVTLPERAALTLNCTYQSSYSTFLFWYVQYLN
KEPELLLKSSENQETDSRGFQASPIKSDSSFHLEKPSVQLSDSAVYYCALR
Target Bioclass
Enzyme
Family
Cyclophilin-type PPIase family, PPIase A subfamily
Subcellular location
Cytoplasm
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Uniprot ID
A0A075B759
Ensemble ID
ENST00000581164.2
HGNC ID
HGNC:33997

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E120(1.12)  LDD2208  [1]
AHL-Pu-1
 Probe Info  		C52(3.10)  LDD0168  [2]
NAIA_5
 Probe Info  		C62(0.00); C52(0.00)  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C52(3.10)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C52(3.02)  LDD0169  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264