Details of the Target

General Information of Target

Target ID LDTP16180
Target Name Zinc finger protein 624 (ZNF624)
Gene Name ZNF624
Gene ID 57547
Synonyms
KIAA1349; Zinc finger protein 624
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDKILEAVVTSSYPVSVKQGLVRRVLEAARQPLEREQCLALLALGARLYVGGAEELPRRV
GCQLLHVAGRHHPDVFAEFFSARRVLRLLQGGAGPPGPRALACVQLGLQLLPEGPAADEV
FALLRREVLRTVCERPGPAACAQVARLLARHPRCVPDGPHRLLFCQQLVRCLGRFRCPAE
GEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCAEEEPPSSALASVVQHL
PLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFS
ILIEVSLTKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVASLVK
EDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQDAWTS
QKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFMASDFRHCVLRLTENNSQPL
MTKLQWLFGFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGT
RICQKLKQSSSPSPPEEPPAPSSTSVEKMFGGKIVTRICCLCCLNVSSREEAFTDLSLAF
PPPERCRRRRLGSVMRPTEDITARELPPPTSAQGPGRVGPRRQRKHCITEDTPPTSLYIE
GLDSKEAGGQSSQEERIEREEEGKEERTEKEEVGEEEESTRGEGEREKEEEVEEEEEKVE
KETEKEAEQEKEEDSLGAGTHPDAAIPSGERTCGSEGSRSVLDLVNYFLSPEKLTAENRY
YCESCASLQDAEKVVELSQGPCYLILTLLRFSFDLRTMRRRKILDDVSIPLLLRLPLAGG
RGQAYDLCSVVVHSGVSSESGHYYCYAREGAARPAASLGTADRPEPENQWYLFNDTRVSF
SSFESVSNVTSFFPKDTAYVLFYRQRPREGPEAELGSSRVRTEPTLHKDLMEAISKDNIL
YLQEQEKEARSRAAYISALPTSPHWGRGFDEDKDEDEGSPGGCNPAGGNGGDFHRLVF
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9P2J8
Ensemble ID
ENST00000311331.12
HGNC ID
HGNC:29254

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KU1919 SNV: p.H830N .
LS180 SNV: p.K498N .
MOLT4 Deletion: p.F459LfsTer33 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C372(1.12)  LDD3323  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
HHS-465
 Probe Info  		K330(0.00); K333(0.00); K666(0.00); K669(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C372(1.13)  LDD1512  [4]
 LDCM0281  AC21 HEK-293T C372(0.98)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C372(0.83)  LDD1521  [4]
 LDCM0289  AC29 HEK-293T C372(0.73)  LDD1528  [4]
 LDCM0291  AC30 HEK-293T C372(0.92)  LDD1530  [4]
 LDCM0298  AC37 HEK-293T C372(1.31)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C372(1.12)  LDD1538  [4]
 LDCM0307  AC45 HEK-293T C372(0.99)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C372(1.22)  LDD1547  [4]
 LDCM0312  AC5 HEK-293T C372(1.01)  LDD1551  [4]
 LDCM0316  AC53 HEK-293T C372(0.99)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C372(0.82)  LDD1556  [4]
 LDCM0323  AC6 HEK-293T C372(1.04)  LDD1562  [4]
 LDCM0325  AC61 HEK-293T C372(1.07)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C372(1.14)  LDD1565  [4]
 LDCM0248  AKOS034007472 HEK-293T C372(1.02)  LDD1511  [4]
 LDCM0368  CL10 HEK-293T C372(1.03)  LDD1572  [4]
 LDCM0409  CL21 HEK-293T C372(0.98)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C372(1.14)  LDD1614  [4]
 LDCM0422  CL33 HEK-293T C372(1.04)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C372(1.01)  LDD1627  [4]
 LDCM0435  CL45 HEK-293T C372(0.92)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C372(1.21)  LDD1640  [4]
 LDCM0448  CL57 HEK-293T C372(1.01)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C372(1.16)  LDD1652  [4]
 LDCM0461  CL69 HEK-293T C372(1.25)  LDD1664  [4]
 LDCM0463  CL70 HEK-293T C372(1.03)  LDD1666  [4]
 LDCM0475  CL81 HEK-293T C372(1.59)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C372(0.92)  LDD1679  [4]
 LDCM0484  CL9 HEK-293T C372(0.97)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C372(0.86)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C372(0.92)  LDD1692  [4]
 LDCM0022  KB02 T cell-activated C542(20.00)  LDD1704  [5]
 LDCM0023  KB03 697 C372(1.40)  LDD2662  [1]
 LDCM0024  KB05 SKMEL24 C372(1.12)  LDD3323  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.