Details of the Target

General Information of Target

Target ID LDTP16160
Target Name Large ribosomal subunit protein bL36m (MRPL36)
Gene Name MRPL36
Gene ID 64979
Synonyms
BRIP1; Large ribosomal subunit protein bL36m; 39S ribosomal protein L36, mitochondrial; L36mt; MRP-L36; BRCA1-interacting protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLY
LGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSC
RVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIA
CGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIEN
CYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEP
SRILSEGANGH
Target Bioclass
Other
Family
Bacterial ribosomal protein bL36 family
Subcellular location
Mitochondrion
Uniprot ID
Q9P0J6
Ensemble ID
ENST00000382647.7
HGNC ID
HGNC:14490

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C76(0.00); C79(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C92(1.19)  LDD3412  [2]
AHL-Pu-1
 Probe Info  		C92(2.80)  LDD0169  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C92(2.80)  LDD0169  [3]
 LDCM0022  KB02 HCC1954 C79(1.63)  LDD2343  [2]
 LDCM0023  KB03 HCC1954 C79(1.70)  LDD2760  [2]
 LDCM0024  KB05 RT-112 C92(1.19)  LDD3412  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264