Details of the Target

General Information of Target

Target ID LDTP16139
Target Name Serine/threonine-protein kinase 32B (STK32B)
Gene Name STK32B
Gene ID 55351
Synonyms
YANK2; Serine/threonine-protein kinase 32B; EC 2.7.11.1; Yet another novel kinase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTMEGASGSSFGIDTILSSASSGSPGMMNGDFRPLGEARTADFRSQATPSPCSEIDTVGT
APSSPISVTMEPPEPHLVADATQHHHHLHHSQQPPPPAAAPTQSLQPLPQQQQPLPPQQP
PPPPPQQLGSAASAPRTSTSSFLIKDILGDSKPLAACAPYSTSVSSPHHTPKQESNAVHE
SFRPKLEQEDSKTKLDKREDSQSDIKCHGTKEEGDREITSSRESPPVRAKKPRKARTAFS
DHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAE
AGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAMYSSMYRTPPAPHPQLQRPLVPRV
LIHGLGPGGQPALNPLSSPIPGTPHPR
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family
TTD ID
T01255
Uniprot ID
Q9NY57
DrugMap ID
TT4D2GZ
Ensemble ID
ENST00000282908.10
HGNC ID
HGNC:14217
ChEMBL ID
CHEMBL5912

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G3R .
CCK81 SNV: p.Y140H .
IGROV1 SNV: p.V37I .
NCIH1048 SNV: p.K329R .
RKO SNV: p.L259R .
RL952 SNV: p.F300L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C38(1.68)  LDD3342  [1]
AHL-Pu-1
 Probe Info  		C309(2.43)  LDD0171  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C309(2.43)  LDD0171  [2]
 LDCM0214  AC1 PaTu 8988t C399(0.71); C408(0.71)  LDD1093  [3]
 LDCM0276  AC17 PaTu 8988t C399(0.84); C408(0.84)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C399(0.81); C408(0.81)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C399(0.99); C408(0.99)  LDD1157  [3]
 LDCM0279  AC2 PaTu 8988t C399(0.72); C408(0.72)  LDD1158  [3]
 LDCM0280  AC20 PaTu 8988t C399(1.01); C408(1.01)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C399(0.95); C408(0.95)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C399(1.00); C408(1.00)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C399(1.31); C408(1.31)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C399(0.80); C408(0.80)  LDD1163  [3]
 LDCM0285  AC25 PaTu 8988t C399(1.23); C408(1.23)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C399(1.03); C408(1.03)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C399(1.08); C408(1.08)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C399(0.97); C408(0.97)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C399(1.07); C408(1.07)  LDD1168  [3]
 LDCM0290  AC3 PaTu 8988t C399(0.81); C408(0.81)  LDD1169  [3]
 LDCM0291  AC30 PaTu 8988t C399(1.10); C408(1.10)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C399(1.10); C408(1.10)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C399(1.39); C408(1.39)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C399(1.23); C408(1.23)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C399(1.09); C408(1.09)  LDD1174  [3]
 LDCM0301  AC4 PaTu 8988t C399(0.83); C408(0.83)  LDD1180  [3]
 LDCM0312  AC5 PaTu 8988t C399(0.92); C408(0.92)  LDD1191  [3]
 LDCM0332  AC68 PaTu 8988t C399(1.22); C408(1.22)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C399(1.17); C408(1.17)  LDD1212  [3]
 LDCM0335  AC70 PaTu 8988t C399(1.27); C408(1.27)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C399(1.25); C408(1.25)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C399(1.40); C408(1.40)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C399(1.69); C408(1.69)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C399(1.31); C408(1.31)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C399(1.13); C408(1.13)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C399(1.09); C408(1.09)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C399(1.34); C408(1.34)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C399(1.61); C408(1.61)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C399(1.41); C408(1.41)  LDD1223  [3]
 LDCM0346  AC80 PaTu 8988t C399(1.06); C408(1.06)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C399(1.39); C408(1.39)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C399(1.49); C408(1.49)  LDD1227  [3]
 LDCM0367  CL1 PaTu 8988t C399(1.09); C408(1.09)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C399(1.05); C408(1.05)  LDD1247  [3]
 LDCM0369  CL100 PaTu 8988t C399(0.92); C408(0.92)  LDD1248  [3]
 LDCM0374  CL105 PaTu 8988t C399(0.90); C408(0.90)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C399(0.97); C408(0.97)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C399(1.07); C408(1.07)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C399(0.74); C408(0.74)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C399(0.99); C408(0.99)  LDD1257  [3]
 LDCM0379  CL11 PaTu 8988t C399(1.03); C408(1.03)  LDD1258  [3]
 LDCM0380  CL110 PaTu 8988t C399(1.11); C408(1.11)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C399(1.18); C408(1.18)  LDD1260  [3]
 LDCM0382  CL112 PaTu 8988t C399(1.42); C408(1.42)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C399(1.22); C408(1.22)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C399(1.06); C408(1.06)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C399(1.06); C408(1.06)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C399(1.01); C408(1.01)  LDD1265  [3]
 LDCM0390  CL12 PaTu 8988t C399(1.26); C408(1.26)  LDD1269  [3]
 LDCM0400  CL13 PaTu 8988t C399(1.12); C408(1.12)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C399(1.34); C408(1.34)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C399(1.45); C408(1.45)  LDD1281  [3]
 LDCM0407  CL2 PaTu 8988t C399(0.98); C408(0.98)  LDD1286  [3]
 LDCM0418  CL3 PaTu 8988t C399(0.91); C408(0.91)  LDD1297  [3]
 LDCM0429  CL4 PaTu 8988t C399(1.03); C408(1.03)  LDD1308  [3]
 LDCM0440  CL5 PaTu 8988t C399(1.06); C408(1.06)  LDD1319  [3]
 LDCM0451  CL6 PaTu 8988t C399(1.28); C408(1.28)  LDD1330  [3]
 LDCM0462  CL7 PaTu 8988t C399(1.12); C408(1.12)  LDD1341  [3]
 LDCM0469  CL76 PaTu 8988t C399(0.66); C408(0.66)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C399(1.09); C408(1.09)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C399(0.86); C408(0.86)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C399(0.81); C408(0.81)  LDD1351  [3]
 LDCM0473  CL8 PaTu 8988t C399(1.34); C408(1.34)  LDD1352  [3]
 LDCM0474  CL80 PaTu 8988t C399(1.24); C408(1.24)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C399(1.38); C408(1.38)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C399(0.83); C408(0.83)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C399(1.00); C408(1.00)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C399(0.92); C408(0.92)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C399(0.82); C408(0.82)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C399(0.73); C408(0.73)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C399(1.08); C408(1.08)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C399(0.88); C408(0.88)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C399(1.38); C408(1.38)  LDD1362  [3]
 LDCM0484  CL9 PaTu 8988t C399(1.12); C408(1.12)  LDD1363  [3]
 LDCM0485  CL90 PaTu 8988t C399(1.18); C408(1.18)  LDD1364  [3]
 LDCM0486  CL91 PaTu 8988t C399(0.89); C408(0.89)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C399(0.92); C408(0.92)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C399(0.91); C408(0.91)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C399(0.82); C408(0.82)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C399(1.25); C408(1.25)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C399(0.80); C408(0.80)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C399(0.81); C408(0.81)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C399(0.87); C408(0.87)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C399(1.04); C408(1.04)  LDD1373  [3]
 LDCM0022  KB02 A-375 C38(1.54)  LDD2255  [1]
 LDCM0023  KB03 A-375 C38(2.03)  LDD2672  [1]
 LDCM0024  KB05 NCI-H1155 C38(1.68)  LDD3342  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid24793884c74 Small molecular drug D0RJ8J

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.