Details of the Target

General Information of Target

Target ID LDTP16012
Target Name Zinc finger protein 442 (ZNF442)
Gene Name ZNF442
Gene ID 79973
Synonyms
Zinc finger protein 442
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSPEIASLSWGQMKVKGSNTTYKDCKVWPGGSRTWDWRETGTEHSPGVQPADVKEVVEK
GVQTLVIGRGMSEALKVPSSTVEYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGVFHS
TC
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9H7R0
Ensemble ID
ENST00000242804.9
HGNC ID
HGNC:20877

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.K296R .
CMK SNV: p.G5V .
HT115 SNV: p.R369I .
HT3 SNV: p.E266Q .
IGR37 SNV: p.S474F .
IGR39 SNV: p.S474F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C239(2.31)  LDD0170  [1]
HHS-465
 Probe Info  		K291(0.00); K294(0.00); Y293(0.00)  LDD2240  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C239(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C239(2.25)  LDD0171  [1]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010