Details of the Target

General Information of Target

Target ID LDTP15961
Target Name Cysteine/serine-rich nuclear protein 2 (CSRNP2)
Gene Name CSRNP2
Gene ID 81566
Synonyms
C12orf22; FAM130A1; TAIP12; Cysteine/serine-rich nuclear protein 2; CSRNP-2; Protein FAM130A1; TGF-beta-induced apoptosis protein 12; TAIP-12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTS
HHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVI
DIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSS
GNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTT
SVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDS
QTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQ
VEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNG
TITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCE
NAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNL
QEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIA
ILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELR
SSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQT
YAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN
Target Bioclass
Transcription factor
Family
AXUD1 family
Subcellular location
Nucleus
Function Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May play a role in apoptosis.
Uniprot ID
Q9H175
Ensemble ID
ENST00000228515.6
HGNC ID
HGNC:16006

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C518(0.95)  LDD1573  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C518(0.95)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C518(0.96)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C518(0.87)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C518(0.94)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C518(1.07)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C518(0.91)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C518(0.89)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C518(0.93)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C518(1.21)  LDD1607  [1]
 LDCM0416  CL28 HEK-293T C518(0.95)  LDD1620  [1]
 LDCM0429  CL4 HEK-293T C518(0.87)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C518(0.86)  LDD1634  [1]
 LDCM0443  CL52 HEK-293T C518(1.00)  LDD1646  [1]
 LDCM0456  CL64 HEK-293T C518(1.01)  LDD1659  [1]
 LDCM0469  CL76 HEK-293T C518(0.93)  LDD1672  [1]
 LDCM0482  CL88 HEK-293T C518(0.87)  LDD1685  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402