Details of the Target

General Information of Target

Target ID LDTP15929
Target Name Leucine-rich repeat and coiled-coil domain-containing protein 1 (LRRCC1)
Gene Name LRRCC1
Gene ID 85444
Synonyms
CLERC; KIAA1764; Leucine-rich repeat and coiled-coil domain-containing protein 1; Centrosomal leucine-rich repeat and coiled-coil domain-containing protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWG
SGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYS
QYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRR
TLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKV
LEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPATVQSRQGDIHELKRTFQALEID
LQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGI
KTHLEKEITTYRRLLEGESEGTREESKSSMKVSATPKIKAITQETINGRLVLCQVNEIQK
HA
Target Bioclass
Other
Family
LRRCC1 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.
Uniprot ID
Q9C099
Ensemble ID
ENST00000360375.8
HGNC ID
HGNC:29373

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.V8A .
DU145 SNV: p.D239N .
HEC1 SNV: p.K889N .
HEC1B SNV: p.K889N .
JURLMK1 SNV: p.K57R .
KMRC3 SNV: p.E684K .
LS123 SNV: p.A12S .
NCIH3122 SNV: p.R544Ter .
RKO Insertion: p.T527NfsTer32 .
RT112 SNV: p.T723N .
SKMEL2 SNV: p.I1018N .
SNGM SNV: p.K732T .
SUIT2 SNV: p.S56F .
SW1271 SNV: p.E744Q .
TKKK SNV: p.D600H .
U937 SNV: p.L111P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C985(3.15)  LDD3423  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C985(0.89)  LDD1520  [2]
 LDCM0289  AC29 HEK-293T C985(0.95)  LDD1528  [2]
 LDCM0298  AC37 HEK-293T C985(0.89)  LDD1537  [2]
 LDCM0307  AC45 HEK-293T C985(1.03)  LDD1546  [2]
 LDCM0312  AC5 HEK-293T C985(0.92)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C985(0.95)  LDD1555  [2]
 LDCM0325  AC61 HEK-293T C985(1.00)  LDD1564  [2]
 LDCM0248  AKOS034007472 HEK-293T C985(0.83)  LDD1511  [2]
 LDCM0369  CL100 HEK-293T C985(1.34)  LDD1573  [2]
 LDCM0373  CL104 HEK-293T C985(1.41)  LDD1577  [2]
 LDCM0377  CL108 HEK-293T C985(1.10)  LDD1581  [2]
 LDCM0382  CL112 HEK-293T C985(0.99)  LDD1586  [2]
 LDCM0386  CL116 HEK-293T C985(1.15)  LDD1590  [2]
 LDCM0391  CL120 HEK-293T C985(1.04)  LDD1595  [2]
 LDCM0395  CL124 HEK-293T C985(1.16)  LDD1599  [2]
 LDCM0399  CL128 HEK-293T C985(1.18)  LDD1603  [2]
 LDCM0403  CL16 HEK-293T C985(1.07)  LDD1607  [2]
 LDCM0409  CL21 HEK-293T C985(1.19)  LDD1613  [2]
 LDCM0416  CL28 HEK-293T C985(0.96)  LDD1620  [2]
 LDCM0422  CL33 HEK-293T C985(0.92)  LDD1626  [2]
 LDCM0429  CL4 HEK-293T C985(1.42)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C985(1.11)  LDD1634  [2]
 LDCM0435  CL45 HEK-293T C985(1.07)  LDD1639  [2]
 LDCM0443  CL52 HEK-293T C985(1.09)  LDD1646  [2]
 LDCM0448  CL57 HEK-293T C985(1.05)  LDD1651  [2]
 LDCM0456  CL64 HEK-293T C985(1.31)  LDD1659  [2]
 LDCM0461  CL69 HEK-293T C985(0.97)  LDD1664  [2]
 LDCM0469  CL76 HEK-293T C985(1.16)  LDD1672  [2]
 LDCM0475  CL81 HEK-293T C985(0.98)  LDD1678  [2]
 LDCM0482  CL88 HEK-293T C985(1.02)  LDD1685  [2]
 LDCM0484  CL9 HEK-293T C985(1.01)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C985(0.95)  LDD1691  [2]
 LDCM0022  KB02 A673 C985(2.15)  LDD2261  [1]
 LDCM0023  KB03 A673 C985(3.44)  LDD2678  [1]
 LDCM0024  KB05 SK-ES1 C985(3.15)  LDD3423  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402