Details of the Target
General Information of Target
| Target ID | LDTP15847 | |||||
|---|---|---|---|---|---|---|
| Target Name | Rho GDP-dissociation inhibitor 3 (ARHGDIG) | |||||
| Gene Name | ARHGDIG | |||||
| Gene ID | 398 | |||||
| Synonyms |
Rho GDP-dissociation inhibitor 3; Rho GDI 3; Rho-GDI gamma |
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| 3D Structure | ||||||
| Sequence |
MDSAAAAFALDKPALGPGPPPPPPALGPGDCAQARKNFSVSHLLDLEEVAAAGRLAARPG
ARAEAREGAAREPSGGSSGSEAAPQDGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQALE RVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQ EAAIEQPVAPRPTALSPDYLSWTASSPYSTVPPYSPGSSGPATPGVNMANSIASLRLKAK EFSLHHSQVPTVN |
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| Target Bioclass |
Other
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| Family |
Rho GDI family
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| Subcellular location |
Cytoplasm
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| Function |
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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TPP-AC Probe Info |
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N.A. | LDD0427 | [1] | |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Other