Details of the Target

General Information of Target

Target ID LDTP15833
Target Name Zinc finger protein 382 (ZNF382)
Gene Name ZNF382
Gene ID 84911
Synonyms
Zinc finger protein 382; KRAB/zinc finger suppressor protein 1; KS1; Multiple zinc finger and krueppel-associated box protein KS1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKL
KASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILP
NVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARR
QPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKL
KVQLDGHERSLQVL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Functions as a sequence-specific transcriptional repressor.
Uniprot ID
Q96SR6
Ensemble ID
ENST00000292928.7
HGNC ID
HGNC:17409

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.I179T .
CORL23 SNV: p.G349E .
G401 SNV: p.N534D .
KATOIII SNV: p.H42R .
KMS12BM SNV: p.H483Y .
MEWO SNV: p.F249I .
MFE319 SNV: p.F352V .
MM1S SNV: p.S268C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C522(2.31)  LDD0170  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C522(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C522(2.25)  LDD0171  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.