Details of the Target

General Information of Target

Target ID LDTP15798
Target Name Contactin-associated protein-like 3B (CNTNAP3B)
Gene Name CNTNAP3B
Gene ID 728577
Synonyms
CASPR3B; Contactin-associated protein-like 3B; Cell recognition molecule Caspr3b
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPALALVSFEDVVVTFTGEEWGHLDLAQRTLYQEVMLETCRLLVSLGHPVPKPELIYL
LEHGQELWTVKRGLSQSTCAGEKAKPKITEPTASQLAFSEESSFQELLAQRSSRDSRLGQ
ARDEEKLIKIQEGNLRPGTNPHKEICPEKLSYKHDDLEPDDSLGLRVLQERVTPQDALHE
CDSQGPGKDPMTDARNNPYTCTECGKGFSKKWALVRHQQIHAGVKPYECNECGKACRYMA
DVIRHMRLHTGEKPYKCIECGKAFKRRFHLTEHQRIHTGDKPYECKECGKAFTHRSSFIQ
HNMTHTREKPFLCKECGKAFYYSSSFAQHMRIHTGKKLYECGECGKAFTHRSTFIQHNVT
HTGEKPFLCKECGKTFCLNSSFTQHMRIHTGEKPYECGECGKAFTHRSTFIRHKRTHTGE
KPFECKECGKAFCDSSSLIQHMRIHTGEKPYECSECGKAFTHHSVFIRHNRTHSGQKPLE
CKECAKAFYYSSSFTRHMRIHTGEKPYVCRECGKAFTQPANFVRHNRIHTGEKPFECKEC
EKAFCDNFALTQHMRTHTGEKPFECNECGKTFSHSSSFTHHRKIHTRV
Target Bioclass
Other
Family
Neurexin family
Subcellular location
Membrane
Uniprot ID
Q96NU0
Ensemble ID
ENST00000377561.7
HGNC ID
HGNC:32035

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1203(2.93)  LDD3383  [1]
WYneN
 Probe Info  		N.A.  LDD0021  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C1167(0.95)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C1167(0.90)  LDD1575  [3]
 LDCM0373  CL104 HEK-293T C1167(0.88)  LDD1577  [3]
 LDCM0375  CL106 HEK-293T C1167(0.96)  LDD1579  [3]
 LDCM0377  CL108 HEK-293T C1167(1.41)  LDD1581  [3]
 LDCM0380  CL110 HEK-293T C1167(0.85)  LDD1584  [3]
 LDCM0382  CL112 HEK-293T C1167(1.48)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C1167(0.85)  LDD1588  [3]
 LDCM0386  CL116 HEK-293T C1167(1.01)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C1167(0.93)  LDD1592  [3]
 LDCM0391  CL120 HEK-293T C1167(1.17)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C1167(1.08)  LDD1597  [3]
 LDCM0395  CL124 HEK-293T C1167(0.97)  LDD1599  [3]
 LDCM0397  CL126 HEK-293T C1167(1.44)  LDD1601  [3]
 LDCM0399  CL128 HEK-293T C1167(1.06)  LDD1603  [3]
 LDCM0401  CL14 HEK-293T C1167(1.10)  LDD1605  [3]
 LDCM0403  CL16 HEK-293T C1167(1.02)  LDD1607  [3]
 LDCM0407  CL2 HEK-293T C1167(1.04)  LDD1611  [3]
 LDCM0414  CL26 HEK-293T C1167(0.87)  LDD1618  [3]
 LDCM0416  CL28 HEK-293T C1167(1.02)  LDD1620  [3]
 LDCM0429  CL4 HEK-293T C1167(1.72)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C1167(0.80)  LDD1634  [3]
 LDCM0441  CL50 HEK-293T C1167(0.84)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C1167(1.21)  LDD1646  [3]
 LDCM0454  CL62 HEK-293T C1167(0.92)  LDD1657  [3]
 LDCM0456  CL64 HEK-293T C1167(1.41)  LDD1659  [3]
 LDCM0467  CL74 HEK-293T C1167(0.91)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C1167(1.25)  LDD1672  [3]
 LDCM0480  CL86 HEK-293T C1167(1.02)  LDD1683  [3]
 LDCM0482  CL88 HEK-293T C1167(1.40)  LDD1685  [3]
 LDCM0493  CL98 HEK-293T C1167(0.99)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C1167(0.96)  LDD1631  [3]
 LDCM0022  KB02 A2058 C1203(2.01)  LDD2253  [1]
 LDCM0023  KB03 A-549 C1203(2.03)  LDD2677  [1]
 LDCM0024  KB05 OVCAR-5 C1203(2.93)  LDD3383  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402