Details of the Target

General Information of Target

Target ID LDTP15769
Target Name Sorting nexin-22 (SNX22)
Gene Name SNX22
Gene ID 79856
Synonyms
Sorting nexin-22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPRELSEAEPPPLRAPTPPPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCNGYPARY
RPTALDTFSVQVLVDGAPVRIELWDTAGQEDFDRLRSLCYPDTDVFLACFSVVQPSSFQN
ITEKWLPEIRTHNPQAPVLLVGTQADLRDDVNVLIQLDQGGREGPVPQPQAQGLAEKIRA
CCYLECSALTQKNLKEVFDSAILSAIEHKARLEKKLNAKGVRTLSRCRWKKFFCFV
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Cytoplasmic vesicle membrane
Function May be involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Uniprot ID
Q96L94
Ensemble ID
ENST00000325881.9
HGNC ID
HGNC:16315

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C33(2.67)  LDD3339  [1]
IA-alkyne
 Probe Info  		C33(3.49); C184(1.65)  LDD2182  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C33(1.05); C184(1.34)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C33(1.34)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C184(2.82)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C33(1.20)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C33(0.76)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C33(1.16); C184(0.82)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C33(1.12)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C33(0.90)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C33(1.17)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C33(0.76)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C33(0.73); C184(0.78)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C33(1.18)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C33(0.82)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C33(1.07)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C33(0.88)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C33(0.79)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C33(1.95); C184(1.06)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C33(1.40)  LDD2204  [2]
 LDCM0569  Fragment7 Ramos C33(1.63); C184(1.16)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C33(1.21)  LDD2188  [2]
 LDCM0022  KB02 Ramos C33(3.49); C184(1.65)  LDD2182  [2]
 LDCM0023  KB03 Ramos C33(1.48); C184(1.00)  LDD2183  [2]
 LDCM0024  KB05 NALM-6 C33(2.67)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578