Details of the Target

General Information of Target

Target ID LDTP15735
Target Name Protein FMC1 homolog (FMC1)
Gene Name FMC1
Gene ID 100996928
Synonyms
C7orf55; Protein FMC1 homolog; ATP synthase assembly factor FMC1, mitochondrial; Formation of mitochondrial complex V assembly factor 1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPKFKQRRRKLKAKAERLFKKKEASHFQSKLITPPPPPPSPERVGISSIDISQSRSWLTS
SWNFNFPNIRDAIKLWTNRVWSIYSWCQNCITQSLEVLKDTIFPSRICHRELYSVKQQFC
ILESKLCKLQEALKTISESSSCPSCGQTCHMSGKLTNVPACVLITPGDSKAVLPPTLPQP
ASHFPPPPPPPPLPPPPPPLAPVLLRKPSLAKALQAGPLKKDGPMQITVKDLLTVKLKKT
QSLDEKRKLIPSPKARNPLVTVSDLQHVTLKPNSKVLSTRVTNVLITPGKSQMDLRKLLR
KVDVERSPGGTPLTNKENMETGTGLTPVMTQALRRKFQLAHPRSPTPTLPLSTSSFDEQN
Target Bioclass
Other
Family
FMC1 family
Subcellular location
Mitochondrion
Function Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V).
Uniprot ID
Q96HJ9
Ensemble ID
ENST00000297534.7
HGNC ID
HGNC:26946

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K101(8.75); K40(1.27)  LDD0277  [2]
DBIA
 Probe Info  		C68(1.70)  LDD3314  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
Phosphinate-6
 Probe Info  		C68(0.00); C53(0.00)  LDD0018  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0625  F8 Ramos C53(1.75)  LDD2187  [10]
 LDCM0573  Fragment11 Ramos C53(2.93)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C53(0.61)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C53(0.77)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C53(0.37)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C53(0.35)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C53(0.63)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C53(0.54)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C53(0.58)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C53(0.80)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C53(0.94)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C53(0.54)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C53(3.14)  LDD2201  [10]
 LDCM0468  Fragment33 Ramos C53(0.99)  LDD2202  [10]
 LDCM0596  Fragment38 Ramos C53(0.57)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C53(0.62)  LDD2184  [10]
 LDCM0610  Fragment52 Ramos C53(1.02)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C53(1.50)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C53(0.54)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C53(1.04)  LDD2188  [10]
 LDCM0022  KB02 42-MG-BA C68(1.24)  LDD2244  [3]
 LDCM0023  KB03 Ramos C53(0.66)  LDD2183  [10]
 LDCM0024  KB05 IGR37 C68(1.70)  LDD3314  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C68(1.51)  LDD2206  [11]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.