Details of the Target

General Information of Target

Target ID LDTP15707
Target Name Pancreatic adenocarcinoma up-regulated factor (ZG16B)
Gene Name ZG16B
Gene ID 124220
Synonyms
PAUF; Pancreatic adenocarcinoma up-regulated factor; Zymogen granule protein 16 homolog B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSSQISLRMKHGRVNMQKKPSKCSECGKFFTQRSSLTQHQRIHRGEKPYVCSECGSCFR
KQSNLTQHLRIHTGEKPYKCNECEKAFQTKAILVQHLRIHTGEKPYKCNECGKAFCQSPS
LIKHQRIHTGEKPYKCTECGKAFSQSICLTRHQRSHSGDKPFKCNECGKAFNQSACLMQH
QRIHSGEKPYTCTECGKAFTQNSSLVEHERTHTGEKLYKCSECEKTFRKQAHLSEHYRIH
TGEKPYECVGCGKSFRHSSALLRHQRLHAGE
Target Bioclass
Other
Family
Jacalin lectin family
Subcellular location
Secreted
Function
Plays an important role in pancreatic tumor progression and metastasis. Promotes pancreatic cancer cells migration and invasion through the TLR4/MyD88/NF-kaapaB signaling pathway, without the involvement of the TLR4/TRIF pathway.
Uniprot ID
Q96DA0
Ensemble ID
ENST00000382280.8
HGNC ID
HGNC:30456

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TER-AC
 Probe Info  		N.A.  LDD0426  [1]
TPP-AC
 Probe Info  		N.A.  LDD0427  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
HAUS augmin-like complex subunit 8 (HAUS8) HAUS8 family Q9BT25
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
Ubiquilin-2 (UBQLN2) . Q9UHD9
Ubiquitin-associated domain-containing protein 1 (UBAC1) . Q9BSL1

References

1 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.