Details of the Target

General Information of Target

Target ID LDTP15678
Target Name ADP-ribosylation factor-like protein 11 (ARL11)
Gene Name ARL11
Gene ID 115761
Synonyms
ARLTS1; ADP-ribosylation factor-like protein 11; ADP-ribosylation factor-like tumor suppressor protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGRRRYDRKQSGYGGQTKPIFRKKA
KTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Arf family
Function May play a role in apoptosis. May act as a tumor suppressor.
Uniprot ID
Q969Q4
Ensemble ID
ENST00000282026.2
HGNC ID
HGNC:24046

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y30(0.83)  LDD0264  [1]
IA-alkyne
 Probe Info  		0.78  LDD2187  [2]
HHS-465
 Probe Info  		Y30(7.78)  LDD2237  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos 0.78  LDD2187  [2]
 LDCM0575  Fragment13 Ramos 1.06  LDD2192  [2]
 LDCM0576  Fragment14 Ramos 1.46  LDD2193  [2]
 LDCM0580  Fragment21 Ramos 0.83  LDD2195  [2]
 LDCM0582  Fragment23 Ramos 2.07  LDD2196  [2]
 LDCM0578  Fragment27 Ramos 0.90  LDD2197  [2]
 LDCM0586  Fragment28 Ramos 1.00  LDD2198  [2]
 LDCM0588  Fragment30 Ramos 1.61  LDD2199  [2]
 LDCM0468  Fragment33 Ramos 1.72  LDD2202  [2]
 LDCM0596  Fragment38 Ramos 0.55  LDD2203  [2]
 LDCM0614  Fragment56 Ramos 1.30  LDD2205  [2]
 LDCM0116  HHS-0101 DM93 Y30(0.83)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y30(0.84)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y30(0.77)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y30(0.88)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y30(1.19)  LDD0268  [1]

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.