Details of the Target
General Information of Target
| Target ID | LDTP15622 | |||||
|---|---|---|---|---|---|---|
| Target Name | Protein Churchill (CHURC1) | |||||
| Gene Name | CHURC1 | |||||
| Gene ID | 91612 | |||||
| Synonyms |
C14orf52; CHCH; Protein Churchill |
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| 3D Structure | ||||||
| Sequence |
MSISLSSLILLPIWINMAQIQQGGPDEKEKTTALKDLLSRIDLDELMKKDEPPLDFPDTL
EGFEYAFNEKGQLRHIKTGEPFVFNYREDLHRWNQKRYEALGEIITKYVYELLEKDCNLK KVSIPVDATESEPKSFIFMSEDALTNPQKLMVLIHGSGVVRAGQWARRLIINEDLDSGTQ IPFIKRAVAEGYGVIVLNPNENYIEVEKPKIHVQSSSDSSDEPAEKRERKDKVSKETKKR RDFYEKYRNPQREKEMMQLYIRENGSPEEHAIYVWDHFIAQAAAENVFFVAHSYGGLAFV ELMIQREADVKNKVTAVALTDSVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESM LPDCPRVSAGTDRHELTSWKSFPSIFKFFTEASEAKTSSLKPAVTRRSHRIKHEEL |
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| Target Bioclass |
Other
|
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| Family |
Churchill family
|
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| Function | Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement.; [Isoform 4]: Does not bind DNA by itself. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
IPM Probe Info |
 |
N.A. | LDD0241 | [1] | |
|
DBIA Probe Info |
 |
C92(1.27) | LDD3329 | [2] | |
|
BTD Probe Info |
 |
C91(1.10) | LDD2093 | [3] | |
|
4-Iodoacetamidophenylacetylene Probe Info |
 |
C64(0.00); C61(0.00) | LDD0038 | [4] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0162 | [5] | |
|
IPIAA_L Probe Info |
 |
N.A. | LDD0031 | [6] | |
|
Lodoacetamide azide Probe Info |
 |
N.A. | LDD0037 | [4] | |
|
NAIA_5 Probe Info |
 |
C64(0.00); C61(0.00) | LDD2223 | [7] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C91(1.13) | LDD2117 | [3] |
| LDCM0558 | 2-Cyano-N-phenylacetamide | MDA-MB-231 | C91(1.12) | LDD2152 | [3] |
| LDCM0022 | KB02 | A2780 | C92(1.36) | LDD2254 | [2] |
| LDCM0023 | KB03 | CMK | C92(0.93) | LDD2719 | [2] |
| LDCM0024 | KB05 | RAW264.7 | C92(1.27) | LDD3329 | [2] |
| LDCM0500 | Nucleophilic fragment 13a | MDA-MB-231 | C91(1.10) | LDD2093 | [3] |
| LDCM0504 | Nucleophilic fragment 15a | MDA-MB-231 | C91(1.21) | LDD2097 | [3] |
| LDCM0508 | Nucleophilic fragment 17a | MDA-MB-231 | C91(1.02) | LDD2101 | [3] |
| LDCM0516 | Nucleophilic fragment 21a | MDA-MB-231 | C91(0.83) | LDD2109 | [3] |
| LDCM0522 | Nucleophilic fragment 24a | MDA-MB-231 | C91(0.76) | LDD2115 | [3] |
| LDCM0526 | Nucleophilic fragment 26a | MDA-MB-231 | C91(1.54) | LDD2119 | [3] |
| LDCM0552 | Nucleophilic fragment 6a | MDA-MB-231 | C91(1.11) | LDD2146 | [3] |
The Interaction Atlas With This Target
References