Details of the Target

General Information of Target

Target ID LDTP15613
Target Name Immunoglobulin superfamily DCC subclass member 4 (IGDCC4)
Gene Name IGDCC4
Gene ID 57722
Synonyms
DDM36; KIAA1628; NOPE; Immunoglobulin superfamily DCC subclass member 4; Neighbor of punc e11; Protein DDM36; hDDM36
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADRGGVGEAAAVGASPASVPGLNPTLGWRERLRAGLAGTGASLWFVAGLGLLYALRIPL
RLCENLAAVTVFLNSLTPKFYVALTGTSSLISGLIFIFEWWYFHKHGTSFIEQVSVSHLQ
PLMGGTESSISEPGSPSRNRENETSRQNLSECKVWRNPLNLFRGAEYRRYTWVTGKEPLT
YYDMNLSAQDHQTFFTCDTDFLRPSDTVMQKAWRERNPPARIKAAYQALELNNDCATAYV
LLAEEEATTIVDAERLFKQALKAGETIYRQSQQCQHQSPQHEAQLRRDTNVLVYIKRRLA
MCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYPDVQAVLAKYDDISL
PKSAAICYTAALLKTRTVSEKFSPETASRRGLSTAEINAVEAIHRAVEFNPHVPKYLLEM
KSLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTFRMIPYPLEKGHLF
YPYPSCTETADRELLPTFHHVSVYPKKELPLFIHFTAGFCSSTAMIAILTHQFPEIMGIF
AKAVLGLWCPQPWASSGFEENTQDLKSEDLGLSSG
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, DCC family
Subcellular location
Cell membrane
Uniprot ID
Q8TDY8
Ensemble ID
ENST00000352385.3
HGNC ID
HGNC:13770

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.P753S .
COLO792 SNV: p.A511P .
ECC2 SNV: p.E494K .
HT Deletion: p.A611PfsTer26 .
IGROV1 SNV: p.G681R; p.K1114N .
KATOIII SNV: p.R1006W .
KMS11 SNV: p.A1005D .
KYSE410 SNV: p.A437V; p.P1234S .
LOXIMVI Deletion: p.H1025IfsTer45 .
LS123 SNV: p.A606P; p.R666W .
MOLT4 SNV: p.A267V .
OE33 SNV: p.A300S .
SUPT1 SNV: p.V422M .
TOV21G SNV: p.R926C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1233(1.03)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C1233(1.03)  LDD1508  [1]
 LDCM0277  AC18 HEK-293T C1233(1.06)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C1233(1.13)  LDD1518  [1]
 LDCM0286  AC26 HEK-293T C1233(0.96)  LDD1525  [1]
 LDCM0295  AC34 HEK-293T C1233(1.09)  LDD1534  [1]
 LDCM0304  AC42 HEK-293T C1233(1.17)  LDD1543  [1]
 LDCM0313  AC50 HEK-293T C1233(1.06)  LDD1552  [1]
 LDCM0321  AC58 HEK-293T C1233(0.99)  LDD1560  [1]
 LDCM0369  CL100 HEK-293T C1233(0.91)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C1233(0.98)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C1233(0.91)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C1233(1.01)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C1233(0.97)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C1233(0.91)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C1233(1.00)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C1233(0.90)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C1233(0.97)  LDD1607  [1]
 LDCM0405  CL18 HEK-293T C1233(1.08)  LDD1609  [1]
 LDCM0416  CL28 HEK-293T C1233(1.03)  LDD1620  [1]
 LDCM0419  CL30 HEK-293T C1233(0.97)  LDD1623  [1]
 LDCM0429  CL4 HEK-293T C1233(0.96)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C1233(0.96)  LDD1634  [1]
 LDCM0432  CL42 HEK-293T C1233(1.01)  LDD1636  [1]
 LDCM0443  CL52 HEK-293T C1233(1.05)  LDD1646  [1]
 LDCM0445  CL54 HEK-293T C1233(1.10)  LDD1648  [1]
 LDCM0451  CL6 HEK-293T C1233(0.90)  LDD1654  [1]
 LDCM0456  CL64 HEK-293T C1233(0.99)  LDD1659  [1]
 LDCM0458  CL66 HEK-293T C1233(1.11)  LDD1661  [1]
 LDCM0469  CL76 HEK-293T C1233(1.03)  LDD1672  [1]
 LDCM0471  CL78 HEK-293T C1233(0.84)  LDD1674  [1]
 LDCM0482  CL88 HEK-293T C1233(1.01)  LDD1685  [1]
 LDCM0485  CL90 HEK-293T C1233(0.96)  LDD1688  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402