Details of the Target

General Information of Target

Target ID LDTP15464
Target Name Zinc finger protein 441 (ZNF441)
Gene Name ZNF441
Gene ID 126068
Synonyms
Zinc finger protein 441
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKPAGRKKKTPTPREEADVQKSALREEKVSGDRKPPERPTVPRKPRTEPCLSPEDEEHV
FDAFDASFKDDFEGVPVFIPFQRKKPYECSECGRIFKHKTDHIRHQRVHTGEKPFKCAQC
GKAFRHSSDVTKHQRTHTGEKPFKCGECGKAFNCGSNLLKHQKTHTGEKPYECTHCGKAF
AYSSCLIRHQKRHPRKKP
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8N8Z8
Ensemble ID
ENST00000357901.5
HGNC ID
HGNC:20875

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.H50D .
CCK81 SNV: p.S24P .
COLO792 SNV: p.Q547Ter .
CORL88 SNV: p.S517Ter .
HT115 SNV: p.E675Ter .
MOLT4 SNV: p.R519Ter .
REC1 SNV: p.A372G .
SW1783 SNV: p.R324Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C338(2.31)  LDD0170  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C338(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C338(2.25)  LDD0171  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proprotein convertase subtilisin/kexin type 6 (PCSK6) Peptidase S8 family P29122
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Syntaxin-1A (STX1A) Syntaxin family Q16623
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Protein sprouty homolog 1 (SPRY1) Sprouty family O43609
Testis-expressed protein 48 (TEX48) . A0A1B0GUV7

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625