Details of the Target

General Information of Target

Target ID LDTP15368
Target Name Zinc finger protein 34 (ZNF34)
Gene Name ZNF34
Gene ID 80778
Synonyms
KOX32; Zinc finger protein 34; Zinc finger protein KOX32
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEPQPPRPPASMALLGSQHSGAPSAAGPPGGTSSAATAAVLSFSTVATAALGNLSDASG
GGTAAAPGGGGLGGSGAAREAGAAVRRPLGPEAAPLLSHGAAVAAQALVLLLIFLLSSLG
NCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAAAGPW
RGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGF
SLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHI
CKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQAQ
TMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNISMLLGRNREEGYRTRNVDAFLPSQGP
GLQARSRSRLRNRYANRLGACNRMSSSNPASGVAGDVAMWARKNPVVLFCREGPPEPVTA
VTKQPKSEAGDTSL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8IZ26
Ensemble ID
ENST00000343459.8
HGNC ID
HGNC:13098

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C292(1.63)  LDD3377  [1]
IA-alkyne
 Probe Info  		C393(8.39)  LDD0315  [2]
HHS-465
 Probe Info  		K333(0.00); K336(0.00); Y335(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C292(0.85)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C292(0.91)  LDD1508  [4]
 LDCM0259  AC14 HEK-293T C292(0.90)  LDD1512  [4]
 LDCM0276  AC17 HEK-293T C292(1.05)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C292(0.95)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C292(0.89)  LDD1518  [4]
 LDCM0282  AC22 HEK-293T C292(0.91)  LDD1521  [4]
 LDCM0285  AC25 HEK-293T C292(0.98)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C292(1.05)  LDD1525  [4]
 LDCM0291  AC30 HEK-293T C292(0.79)  LDD1530  [4]
 LDCM0294  AC33 HEK-293T C292(1.18)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C292(1.17)  LDD1534  [4]
 LDCM0299  AC38 HEK-293T C292(0.85)  LDD1538  [4]
 LDCM0303  AC41 HEK-293T C292(0.99)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C292(1.44)  LDD1543  [4]
 LDCM0308  AC46 HEK-293T C292(1.10)  LDD1547  [4]
 LDCM0311  AC49 HEK-293T C292(1.17)  LDD1550  [4]
 LDCM0313  AC50 HEK-293T C292(0.91)  LDD1552  [4]
 LDCM0317  AC54 HEK-293T C292(0.84)  LDD1556  [4]
 LDCM0320  AC57 HEK-293T C292(1.08)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C292(1.03)  LDD1560  [4]
 LDCM0323  AC6 HEK-293T C292(1.00)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C292(1.20)  LDD1565  [4]
 LDCM0356  AKOS034007680 HEK-293T C292(1.13)  LDD1570  [4]
 LDCM0368  CL10 HEK-293T C292(0.91)  LDD1572  [4]
 LDCM0404  CL17 HEK-293T C292(1.13)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C292(1.00)  LDD1609  [4]
 LDCM0410  CL22 HEK-293T C292(1.06)  LDD1614  [4]
 LDCM0417  CL29 HEK-293T C292(1.03)  LDD1621  [4]
 LDCM0419  CL30 HEK-293T C292(0.90)  LDD1623  [4]
 LDCM0423  CL34 HEK-293T C292(0.94)  LDD1627  [4]
 LDCM0431  CL41 HEK-293T C292(1.00)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C292(0.79)  LDD1636  [4]
 LDCM0436  CL46 HEK-293T C292(1.00)  LDD1640  [4]
 LDCM0440  CL5 HEK-293T C292(0.98)  LDD1644  [4]
 LDCM0444  CL53 HEK-293T C292(1.17)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C292(1.06)  LDD1648  [4]
 LDCM0449  CL58 HEK-293T C292(1.07)  LDD1652  [4]
 LDCM0451  CL6 HEK-293T C292(0.80)  LDD1654  [4]
 LDCM0457  CL65 HEK-293T C292(1.22)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C292(0.97)  LDD1661  [4]
 LDCM0463  CL70 HEK-293T C292(0.91)  LDD1666  [4]
 LDCM0470  CL77 HEK-293T C292(1.32)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C292(0.65)  LDD1674  [4]
 LDCM0476  CL82 HEK-293T C292(0.92)  LDD1679  [4]
 LDCM0483  CL89 HEK-293T C292(0.91)  LDD1686  [4]
 LDCM0485  CL90 HEK-293T C292(0.97)  LDD1688  [4]
 LDCM0489  CL94 HEK-293T C292(1.12)  LDD1692  [4]
 LDCM0022  KB02 HEK-293T C292(0.94)  LDD1492  [4]
 LDCM0023  KB03 Jurkat C393(8.39)  LDD0315  [2]
 LDCM0024  KB05 OPM-2 C292(1.63)  LDD3377  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402