Details of the Target

General Information of Target

Target ID LDTP15365
Target Name Cilia- and flagella-associated protein 46 (CFAP46)
Gene Name CFAP46
Gene ID 54777
Synonyms
C10orf123; C10orf124; C10orf92; C10orf93; TTC40; Cilia- and flagella-associated protein 46; Tetratricopeptide repeat protein 40
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWHAISRTSRMSQSGCPSGLLADKNISSSATRVIVKTAGNQKDFMVADDISVRQFKEMLL
AHFQCQMDQLVLVFMGCLLKDHDTLSQRGIMDGHTIYLVIKSKQGSRSLAHSFRDLPTND
PCHRDRNTKGNSSRVHQPTGMNQAPVELAHFVGSDAPKVHTQNLEVSHPECKAQMLENPS
IQRLLSNMEFMWQFISEHLDTQQLMQQNPEVSRLLLDNSEILLQTLELARNLAMIQEIMQ
IQQPSQNLEYPLNPQPYLGLETMPGGNNALGQNYADINDQMLNSMQDPFGGNPFTALLAG
QVLEQVQSSPPPPPPSQEQQDQLTQHPATRVIYNSSGGFSSNTSANDTLNKVNHTSKANT
AMISTKGQSHICATRQPAWIPALPSIELTQQLQEEYKDATVSLSSSRQTLKGDLQLSDEQ
SSSQITGGMMQLLMNNPYLAAQIMLFTSMPQLSEQWRQQLPTFLQQTQISDLLSA
Target Bioclass
Other
Family
CFAP46 family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function As part of the central apparatus of the cilium axoneme plays a role in cilium movement.
Uniprot ID
Q8IYW2
Ensemble ID
ENST00000368585.3
HGNC ID
HGNC:25247

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A2186V; p.A2196T .
CALU6 SNV: p.R544L .
CCK81 Deletion: p.P2405LfsTer5 .
DU145 SNV: p.A515S; p.Q858H .
G415 Deletion: p.L939DfsTer12 .
HCT15 SNV: p.H1332Y; p.A1907T .
HEC1 Deletion: p.V1485CfsTer2
SNV: p.G1817D		 .
HEC1B Deletion: p.V1485CfsTer2
SNV: .		 .
HT115 SNV: p.E122K; p.H1121L; p.Q1124H; p.K1363T; p.S1435P; p.E2357Ter .
HUH7 Insertion: p.I328YfsTer2 .
ICC106 SNV: p.G2205A .
IGROV1 SNV: p.K191N .
KYM1 Insertion: p.T1805NfsTer17 .
LS180 Insertion: p.Y1909LfsTer7 .
MELJUSO Deletion: p.K23del
SNV: p.G2380R		 .
MEWO SNV: p.E331K .
MFE319 SNV: p.Q525L; p.S530I; p.Y1327C; p.K1659N .
MOLT4 Deletion: p.P2653QfsTer47
SNV: p.L88M;p.V630A		 .
NCIH1155 SNV: p.S1120R .
NCIH1703 SNV: p.K1210N .
NCIH2286 Deletion: p.A1057PfsTer2
SNV: p.R1787L		 .
NCIH2291 SNV: p.A523T; p.E683G; p.Q1564Ter .
NCIH358 SNV: p.A600G .
NUGC3 SNV: p.G1947S .
RKO SNV: p.Q738Ter; p.H1744N .
RL952 SNV: p.A2115V .
SBC5 SNV: p.D821Y .
SKMEL24 SNV: p.L605F .
SKMEL28 SNV: p.A600G .
SKMEL3 SNV: p.A2104D; p.A2106S .
SUPT1 SNV: p.F73V; p.G1091S .
SW1271 SNV: p.Q2263L .
SW403 SNV: p.L186M; p.Q1216H .
TE8 SNV: p.E887Q .
UMUC3 SNV: p.E483Q; p.A1931S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C549(2.68)  LDD3372  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
1d-yne
 Probe Info  		N.A.  LDD0357  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 HCC1187 C549(1.29)  LDD2337  [1]
 LDCM0023  KB03 HCC1187 C549(1.95)  LDD2754  [1]
 LDCM0024  KB05 OCI-Ly3 C549(2.68)  LDD3372  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
4 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.