Details of the Target

General Information of Target

Target ID LDTP15325
Target Name Zinc finger protein 573 (ZNF573)
Gene Name ZNF573
Gene ID 126231
Synonyms
Zinc finger protein 573
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVDLLSAQEPVTFRDVAVFFSQDEWLHLDSAQRALYREVMLENYSSLVSLGIPFSMPKL
IHQLQQGEDPCMVEREVPSDTRLGFKTWLETEALPHRQDIFIEETSQGMVKKESIKDGHW
DINFEEAVEFESEIEEEQEKKPLRQMIDSHEKTISEDGNHTSLELGKSLFTNTALVTQQS
VPIERIPNMYYTFGKDFKQNFDLMKCFQIYPGGKPHICNECGKSFKQNLHLIEHQRIHTG
EKPYKCNECEKTFSHRSSLLSHQRIHTGEKPYKCNECEKAFSNSSTLIKHLRVHTGEKPY
RCRECGKAFSQCSTLTVHQRIHTGEKLYKCGECEKAFNCRAKLHRHQRIHTGEKPYKCSE
CGKGYSQFTSLAEHQRFHTGEQLYTCLECGRTFTRIVTLIEHQRIHTGQKPYQCNECEKA
FNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIHTGEKPYQCNQCGKAFSQY
SFLTEHERIHTGEKLYKCMECGKAYSYRSNLCRHKKVHTKEKLYKWKEYGKPFICSSSLT
QYQRFFKGDKAYEV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q86YE8
Ensemble ID
ENST00000339503.7
HGNC ID
HGNC:26420

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.K580NfsTer84 .
HT SNV: p.A310V .
KYM1 Substitution: p.T318R .
KYSE510 SNV: p.D55Y .
MDAMB157 SNV: p.S287Ter .
MEWO SNV: p.H240Y; p.S399L .
NCIH661 SNV: p.C104F .
RKN SNV: p.D32V .
SW1573 SNV: p.E59G .
YSCCC SNV: p.E495K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y498(20.00)  LDD0257  [1]
AHL-Pu-1
 Probe Info  		C416(2.31)  LDD0170  [2]
Acrolein
 Probe Info  		N.A.  LDD0227  [3]
HHS-465
 Probe Info  		K496(0.00); K499(0.00); Y498(0.00)  LDD2240  [4]
HHS-482
 Probe Info  		Y274(1.28)  LDD2239  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C416(2.31)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C416(2.25)  LDD0171  [2]
 LDCM0109  NEM HeLa N.A.  LDD0227  [3]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.