Details of the Target

General Information of Target

Target ID LDTP15319
Target Name Protein Niban 3 (NIBAN3)
Gene Name NIBAN3
Gene ID 199786
Synonyms
BCNP1; FAM129C; Protein Niban 3; B-cell novel protein 1; Niban-like protein 2; Protein FAM129C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKILVAFLVVLTIFGIQSHGYEVFNIISPSNNGGNVQETVTIDNEKNTAIINIHAGSCSS
TTIFDYKHGYIASRVLSRRACFILKMDHQNIPPLNNLQWYIYEKQALDNMFSSKYTWVKY
NPLESLIKDVDWFLLGSPIEKLCKHIPLYKGEVVENTHNVGAGGCAKAGLLGILGISICA
DIHV
Target Bioclass
Other
Family
Niban family
Uniprot ID
Q86XR2
Ensemble ID
ENST00000332386.9
HGNC ID
HGNC:24130

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C579(2.14); C93(1.39)  LDD3339  [1]
IA-alkyne
 Probe Info  		C62(0.35)  LDD2182  [2]
IPM
 Probe Info  		C579(1.01)  LDD1702  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C579(1.01)  LDD1702  [3]
 LDCM0625  F8 Ramos C62(0.35)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C62(0.57)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C62(0.17)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C62(0.89)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C62(0.78)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C62(0.55)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C62(0.73)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C62(0.70)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C62(0.56)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C62(0.68)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C62(0.87)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C62(0.81)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C62(1.00)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C62(0.76)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C62(0.85)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C62(0.69)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C62(0.69)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C62(0.81)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C62(1.06)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C62(0.45)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C62(0.72)  LDD2188  [2]
 LDCM0022  KB02 Ramos C62(0.35)  LDD2182  [2]
 LDCM0023  KB03 Ramos C62(0.52)  LDD2183  [2]
 LDCM0024  KB05 NALM-6 C579(2.14); C93(1.39)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761