Details of the Target

General Information of Target

Target ID LDTP15215
Target Name Tubulin epsilon and delta complex protein 2 (TEDC2)
Gene Name TEDC2
Gene ID 80178
Synonyms
C16orf59; Tubulin epsilon and delta complex protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVGGDTAAPAPGGAEDLEDTQFPSEEAREGGGVHAVPPDPEDEGLEETGSKDKDQPPSP
SPPPQSEALSSTSRLWSPAAPENSPTCSPESSSGGQGGDPSDEEWRSQRKHVFVLSEAGK
PIYSRYGSVEALSATMGVMTALVSFVQSAGDAIRAIYAEDHKLVFLQQGPLLLVAMSRTS
QSAAQLRGELLAVHAQIVSTLTRASVARIFAHKQNYDLRRLLAGSERTLDRLLDSMEQDP
GALLLGAVRCVPLARPLRDALGALLRRCTAPGLALSVLAVGGRLITAAQERNVLAECRLD
PADLQLLLDWVGAPAFAAGEAWAPVCLPRFNPDGFFYAYVARLDAMPVCLLLLGTQREAF
HAMAACRRLVEDGMHALGAMRALGEAASFSNASSASAPAYSVQAVGAPGLRHFLYKPLDI
PDHHRQLPQFTSPELEAPYSREEERQRLSDLYHRLHARLHSTSRPLRLIYHVAEKETLLA
WVTSKFELYTCLSPLVTKAGAILVVTKLLRWVKKEEDRLFIRYPPKYSTPPATSTDQAAH
NGLFTGL
Target Bioclass
Other
Subcellular location
Cell projection, cilium
Function Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability.
Uniprot ID
Q7L2K0
Ensemble ID
ENST00000361837.9
HGNC ID
HGNC:25849

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.D162G .
CCK81 SNV: p.P328S .
HCT15 SNV: p.V160M .
ICC4 SNV: p.V90I .
MFE319 SNV: p.E200K; p.W222L .
ONS76 SNV: p.Q183R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C331(0.95); C343(0.95)  LDD0078  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C298(0.85)  LDD1508  [3]
 LDCM0259  AC14 HEK-293T C298(0.85)  LDD1512  [3]
 LDCM0277  AC18 HEK-293T C298(0.70)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C298(0.92)  LDD1518  [3]
 LDCM0282  AC22 HEK-293T C298(0.80)  LDD1521  [3]
 LDCM0286  AC26 HEK-293T C298(0.73)  LDD1525  [3]
 LDCM0291  AC30 HEK-293T C298(0.95)  LDD1530  [3]
 LDCM0295  AC34 HEK-293T C298(1.18)  LDD1534  [3]
 LDCM0299  AC38 HEK-293T C298(0.91)  LDD1538  [3]
 LDCM0304  AC42 HEK-293T C298(1.09)  LDD1543  [3]
 LDCM0308  AC46 HEK-293T C298(0.92)  LDD1547  [3]
 LDCM0313  AC50 HEK-293T C298(1.02)  LDD1552  [3]
 LDCM0317  AC54 HEK-293T C298(1.00)  LDD1556  [3]
 LDCM0321  AC58 HEK-293T C298(0.92)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C298(1.06)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C298(0.83)  LDD1565  [3]
 LDCM0020  ARS-1620 HCC44 C331(0.95); C343(0.95)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C298(1.64)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C298(1.13)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C298(1.68)  LDD1574  [3]
 LDCM0374  CL105 HEK-293T C298(1.26)  LDD1578  [3]
 LDCM0378  CL109 HEK-293T C298(1.12)  LDD1582  [3]
 LDCM0383  CL113 HEK-293T C298(1.43)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C298(1.22)  LDD1591  [3]
 LDCM0392  CL121 HEK-293T C298(1.32)  LDD1596  [3]
 LDCM0396  CL125 HEK-293T C298(1.26)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C298(1.35)  LDD1604  [3]
 LDCM0405  CL18 HEK-293T C298(1.10)  LDD1609  [3]
 LDCM0410  CL22 HEK-293T C298(1.31)  LDD1614  [3]
 LDCM0413  CL25 HEK-293T C298(1.13)  LDD1617  [3]
 LDCM0419  CL30 HEK-293T C298(0.87)  LDD1623  [3]
 LDCM0423  CL34 HEK-293T C298(1.19)  LDD1627  [3]
 LDCM0426  CL37 HEK-293T C298(1.58)  LDD1630  [3]
 LDCM0432  CL42 HEK-293T C298(1.44)  LDD1636  [3]
 LDCM0436  CL46 HEK-293T C298(1.43)  LDD1640  [3]
 LDCM0439  CL49 HEK-293T C298(0.75)  LDD1643  [3]
 LDCM0445  CL54 HEK-293T C298(0.76)  LDD1648  [3]
 LDCM0449  CL58 HEK-293T C298(1.64)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C298(1.07)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C298(1.34)  LDD1656  [3]
 LDCM0458  CL66 HEK-293T C298(1.21)  LDD1661  [3]
 LDCM0463  CL70 HEK-293T C298(1.50)  LDD1666  [3]
 LDCM0466  CL73 HEK-293T C298(1.17)  LDD1669  [3]
 LDCM0471  CL78 HEK-293T C298(1.06)  LDD1674  [3]
 LDCM0476  CL82 HEK-293T C298(1.42)  LDD1679  [3]
 LDCM0479  CL85 HEK-293T C298(1.12)  LDD1682  [3]
 LDCM0485  CL90 HEK-293T C298(1.12)  LDD1688  [3]
 LDCM0489  CL94 HEK-293T C298(1.09)  LDD1692  [3]
 LDCM0492  CL97 HEK-293T C298(1.13)  LDD1695  [3]
 LDCM0022  KB02 HCT 116 C331(20.00); C343(20.00)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C331(20.00); C343(20.00)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C331(6.24); C343(6.24)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402