Details of the Target

General Information of Target

Target ID LDTP15076
Target Name Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1)
Gene Name ITPRIPL1
Gene ID 150771
Synonyms
KIAA1754L; Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQVAVSTLPVEEESSSETRMVVTFLVSALESMCKELAKSKAEVACIAVYETDVFVVGTE
RGCAFVNARTDFQKDFAKYCVAEGLCEVKPPCPVNGMQVHSGETEILRKAVEDYFCFCYG
KALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIIN
RPFLGPESQLGGPGMVTDAERSIVSPSESCGPINVKTEPMEDSGISLKAEAVSVKKESED
PNYYQYNMQGSHPSSTSNEVIEMELPMEDSTPLVPSEEPNEDPEAEVKIEGNTNSSSVTN
SAAGVEDLNIVQVTVPDNEKERLSSIEKIKQLREQVNDLFSRKFGEAIGVDFPVKVPYRK
ITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIRPLPGLELSNVGKRK
IDQEGRVFQEKWERAYFFVEVQNIPTCLICKQSMSVSKEYNLRRHYQTNHSKHYDQYTER
MRDEKLHELKKGLRKYLLGSSDTECPEQKQVFANPSPTQKSPVQPVEDLAGNLWEKLREK
IRSFVAYSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNEIFLRVE
KSLKKFCINWSRLVSVASTGTPAMVDANNGLVTKLKSRVATFCKGAELKSICCIIHPESL
CAQKLKMDHVMDVVVKSVNWICSRGLNHSEFTTLLYELDSQYGSLLYYTEIKWLSRGLVL
KRFFESLEEIDSFMSSRGKPLPQLSSIDWIRDLAFLVDMTMHLNALNISLQGHSQIVTQM
YDLIRAFLAKLCLWETHLTRNNLAHFPTLKLVSRNESDGLNYIPKIAELKTEFQKRLSDF
KLYESELTLFSSPFSTKIDSVHEELQMEVIDLQCNTVLKTKYDKVGIPEFYKYLWGSYPK
YKHHCAKILSMFGSTYICEQLFSIMKLSKTKYCSQLKDSQWDSVLHIAT
Target Bioclass
Enzyme
Family
ITPRIP family
Subcellular location
Membrane
Uniprot ID
Q6GPH6
Ensemble ID
ENST00000361124.5
HGNC ID
HGNC:29371

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.C308Y .
HKGZCC SNV: p.M9K .
JHH7 SNV: p.V377F .
KYSE410 SNV: p.R149H .
LNCaP clone FGC SNV: p.H24R; p.C284Ter .
RKO SNV: p.F339V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C418(0.93)  LDD1509  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C418(0.93)  LDD1509  [1]
 LDCM0270  AC15 HEK-293T C418(0.96)  LDD1513  [1]
 LDCM0278  AC19 HEK-293T C418(0.78)  LDD1517  [1]
 LDCM0283  AC23 HEK-293T C418(0.95)  LDD1522  [1]
 LDCM0287  AC27 HEK-293T C418(0.96)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C418(1.00)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C418(1.01)  LDD1531  [1]
 LDCM0296  AC35 HEK-293T C418(1.00)  LDD1535  [1]
 LDCM0300  AC39 HEK-293T C418(1.05)  LDD1539  [1]
 LDCM0305  AC43 HEK-293T C418(1.01)  LDD1544  [1]
 LDCM0309  AC47 HEK-293T C418(1.04)  LDD1548  [1]
 LDCM0314  AC51 HEK-293T C418(0.96)  LDD1553  [1]
 LDCM0318  AC55 HEK-293T C418(1.08)  LDD1557  [1]
 LDCM0322  AC59 HEK-293T C418(1.05)  LDD1561  [1]
 LDCM0327  AC63 HEK-293T C418(0.99)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C418(1.00)  LDD1568  [1]
 LDCM0367  CL1 HEK-293T C418(1.10)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C418(1.05)  LDD1574  [1]
 LDCM0372  CL103 HEK-293T C418(0.93)  LDD1576  [1]
 LDCM0374  CL105 HEK-293T C418(1.11)  LDD1578  [1]
 LDCM0376  CL107 HEK-293T C418(0.99)  LDD1580  [1]
 LDCM0378  CL109 HEK-293T C418(1.08)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C418(1.10)  LDD1583  [1]
 LDCM0381  CL111 HEK-293T C418(0.95)  LDD1585  [1]
 LDCM0383  CL113 HEK-293T C418(0.96)  LDD1587  [1]
 LDCM0385  CL115 HEK-293T C418(1.04)  LDD1589  [1]
 LDCM0387  CL117 HEK-293T C418(0.97)  LDD1591  [1]
 LDCM0389  CL119 HEK-293T C418(0.97)  LDD1593  [1]
 LDCM0392  CL121 HEK-293T C418(0.96)  LDD1596  [1]
 LDCM0394  CL123 HEK-293T C418(1.16)  LDD1598  [1]
 LDCM0396  CL125 HEK-293T C418(1.03)  LDD1600  [1]
 LDCM0398  CL127 HEK-293T C418(1.03)  LDD1602  [1]
 LDCM0400  CL13 HEK-293T C418(0.94)  LDD1604  [1]
 LDCM0402  CL15 HEK-293T C418(1.14)  LDD1606  [1]
 LDCM0406  CL19 HEK-293T C418(1.01)  LDD1610  [1]
 LDCM0411  CL23 HEK-293T C418(0.98)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C418(1.20)  LDD1617  [1]
 LDCM0415  CL27 HEK-293T C418(1.00)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C418(1.05)  LDD1622  [1]
 LDCM0420  CL31 HEK-293T C418(1.10)  LDD1624  [1]
 LDCM0424  CL35 HEK-293T C418(1.04)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C418(0.99)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C418(0.98)  LDD1632  [1]
 LDCM0433  CL43 HEK-293T C418(1.03)  LDD1637  [1]
 LDCM0437  CL47 HEK-293T C418(1.02)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C418(1.07)  LDD1643  [1]
 LDCM0446  CL55 HEK-293T C418(1.13)  LDD1649  [1]
 LDCM0450  CL59 HEK-293T C418(1.07)  LDD1653  [1]
 LDCM0453  CL61 HEK-293T C418(1.11)  LDD1656  [1]
 LDCM0455  CL63 HEK-293T C418(0.98)  LDD1658  [1]
 LDCM0459  CL67 HEK-293T C418(1.02)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C418(1.01)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C418(1.00)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C418(0.99)  LDD1669  [1]
 LDCM0472  CL79 HEK-293T C418(1.05)  LDD1675  [1]
 LDCM0477  CL83 HEK-293T C418(1.22)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C418(1.12)  LDD1682  [1]
 LDCM0481  CL87 HEK-293T C418(0.90)  LDD1684  [1]
 LDCM0486  CL91 HEK-293T C418(1.04)  LDD1689  [1]
 LDCM0490  CL95 HEK-293T C418(1.07)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C418(1.03)  LDD1695  [1]
 LDCM0494  CL99 HEK-293T C418(0.84)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C418(0.98)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C418(0.92)  LDD1671  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402