Details of the Target

General Information of Target

Target ID LDTP15059
Target Name Transmembrane protein 198 (TMEM198)
Gene Name TMEM198
Gene ID 130612
Synonyms
Transmembrane protein 198
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLLGPASGAPSPLLASLPLPTRPLQPPLDFKHLLAFHFNGAAPLSLFPNFSTMDPVQKAV
ISHTFGVPSPLKKKLFISCNICHLRFNSANQAEAHYKGHKHARKLKAVEAAKSKQRPHTQ
AQDGAVVSPIPTLASGAPGEPQSKVPAAPPLGPPLQPPPTPDPTCREPAHSELLDAASSS
SSSSCPPCSPEPGREAPGPEPAAAAVGSSMSGEGRSEKGHLYCPTCKVTVNSASQLQAHN
TGAKHRWMMEGQRGAPRRSRGRPVSRGGAGHKAKRVTGGRGGRQGPSPAFHCALCQLQVN
SETQLKQHMSSRRHKDRLAGKTPKPSSQHSKLQKHAALAVSILKSKLALQKQLTKTLAAR
FLPSPLPTAATAICALPGPLALRPAPTAATTLFPAPILGPALFRTPAGAVRPATGPIVLA
PY
Target Bioclass
Other
Family
TMEM198 family
Subcellular location
Membrane
Function Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.
Uniprot ID
Q66K66
Ensemble ID
ENST00000344458.6
HGNC ID
HGNC:33704

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C353(0.83)  LDD1512  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C353(0.83)  LDD1512  [1]
 LDCM0282  AC22 HEK-293T C353(0.85)  LDD1521  [1]
 LDCM0291  AC30 HEK-293T C353(1.12)  LDD1530  [1]
 LDCM0299  AC38 HEK-293T C353(0.92)  LDD1538  [1]
 LDCM0308  AC46 HEK-293T C353(0.96)  LDD1547  [1]
 LDCM0317  AC54 HEK-293T C353(1.07)  LDD1556  [1]
 LDCM0323  AC6 HEK-293T C353(1.04)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C353(0.94)  LDD1565  [1]
 LDCM0367  CL1 HEK-293T C353(1.14)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C353(0.72)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C353(1.08)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C353(1.11)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C353(1.09)  LDD1576  [1]
 LDCM0374  CL105 HEK-293T C353(0.92)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C353(1.01)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C353(0.97)  LDD1580  [1]
 LDCM0378  CL109 HEK-293T C353(1.00)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C353(0.90)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C353(1.09)  LDD1585  [1]
 LDCM0383  CL113 HEK-293T C353(0.89)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C353(1.01)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C353(1.08)  LDD1589  [1]
 LDCM0387  CL117 HEK-293T C353(0.67)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C353(1.19)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C353(1.22)  LDD1593  [1]
 LDCM0392  CL121 HEK-293T C353(0.98)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C353(0.93)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C353(1.15)  LDD1598  [1]
 LDCM0396  CL125 HEK-293T C353(0.82)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C353(0.93)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C353(0.97)  LDD1602  [1]
 LDCM0400  CL13 HEK-293T C353(1.07)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C353(0.97)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C353(1.10)  LDD1606  [1]
 LDCM0407  CL2 HEK-293T C353(0.97)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C353(0.66)  LDD1614  [1]
 LDCM0413  CL25 HEK-293T C353(0.83)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C353(0.94)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C353(1.12)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C353(1.15)  LDD1622  [1]
 LDCM0423  CL34 HEK-293T C353(0.65)  LDD1627  [1]
 LDCM0426  CL37 HEK-293T C353(0.79)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C353(1.18)  LDD1632  [1]
 LDCM0436  CL46 HEK-293T C353(0.69)  LDD1640  [1]
 LDCM0439  CL49 HEK-293T C353(1.06)  LDD1643  [1]
 LDCM0441  CL50 HEK-293T C353(1.08)  LDD1645  [1]
 LDCM0449  CL58 HEK-293T C353(0.63)  LDD1652  [1]
 LDCM0453  CL61 HEK-293T C353(0.98)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C353(0.94)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C353(1.14)  LDD1658  [1]
 LDCM0463  CL70 HEK-293T C353(0.72)  LDD1666  [1]
 LDCM0466  CL73 HEK-293T C353(0.74)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C353(1.02)  LDD1670  [1]
 LDCM0476  CL82 HEK-293T C353(0.73)  LDD1679  [1]
 LDCM0479  CL85 HEK-293T C353(0.89)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C353(0.88)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C353(1.05)  LDD1684  [1]
 LDCM0489  CL94 HEK-293T C353(0.77)  LDD1692  [1]
 LDCM0492  CL97 HEK-293T C353(0.87)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C353(0.98)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C353(0.89)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C353(1.04)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C353(1.11)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C353(0.97)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402