Details of the Target

General Information of Target

Target ID LDTP15036
Target Name OTU domain-containing protein 1 (OTUD1)
Gene Name OTUD1
Gene ID 220213
Synonyms
DUBA7; OTDC1; OTU domain-containing protein 1; EC 3.4.19.12; DUBA-7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTPSRLPWLLSWVSATAWRAARSPLLCHSLRKTSSSQGGKSELVKQSLKKPKLPEGRFDA
PEDSHLEKEPLEKFPDDVNPVTKEKGGPRGPEPTRYGDWERKGRCIDF
Target Bioclass
Enzyme
Function
Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation.
Uniprot ID
Q5VV17
Ensemble ID
ENST00000376495.5
HGNC ID
HGNC:27346
ChEMBL ID
CHEMBL4630832

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C320(1.68)  LDD0812  [1]
NAIA_4
 Probe Info  		C53(0.00); C320(0.00)  LDD2226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C320(1.68)  LDD0812  [1]
 LDCM0276  AC17 HEK-293T C320(2.10)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C320(2.22)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C320(2.66)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C320(1.48)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C320(1.59)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C320(3.99)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C320(1.80)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C320(2.78)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C320(2.74)  LDD0882  [1]
 LDCM0290  AC3 HEK-293T C320(1.29)  LDD0888  [1]
 LDCM0301  AC4 HEK-293T C320(1.27)  LDD0899  [1]
 LDCM0312  AC5 HEK-293T C320(1.83)  LDD0910  [1]
 LDCM0349  AC83 HEK-293T C320(0.95)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C320(1.06)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C320(0.97)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C320(1.02)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C320(0.99)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C320(0.99)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C320(1.12)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C320(1.03)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C320(0.98)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C320(0.90)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C320(0.84)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C320(1.00)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C320(1.00)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C320(0.89)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C320(0.92)  LDD0962  [1]
 LDCM0369  CL100 HEK-293T C320(1.41)  LDD0967  [1]
 LDCM0372  CL103 HEK-293T C176(1.17)  LDD1576  [3]
 LDCM0374  CL105 HEK-293T C320(1.57)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C320(1.28)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C320(1.58)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C320(0.83)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C320(1.56)  LDD0976  [1]
 LDCM0380  CL110 HEK-293T C320(1.61)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C320(1.74)  LDD0979  [1]
 LDCM0385  CL115 HEK-293T C176(1.03)  LDD1589  [3]
 LDCM0389  CL119 HEK-293T C176(1.18)  LDD1593  [3]
 LDCM0394  CL123 HEK-293T C176(0.99)  LDD1598  [3]
 LDCM0398  CL127 HEK-293T C176(1.10)  LDD1602  [3]
 LDCM0402  CL15 HEK-293T C176(1.04)  LDD1606  [3]
 LDCM0415  CL27 HEK-293T C176(1.09)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C176(1.08)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C320(0.90)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C320(1.39)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C320(0.91)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C320(1.08)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C320(1.02)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C320(1.15)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C320(0.74)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C320(0.73)  LDD1026  [1]
 LDCM0430  CL40 HEK-293T C320(0.95)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C320(0.95)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C320(1.05)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C320(0.90)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C320(0.83)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C320(1.31)  LDD1033  [1]
 LDCM0455  CL63 HEK-293T C176(1.13)  LDD1658  [3]
 LDCM0481  CL87 HEK-293T C176(1.09)  LDD1684  [3]
 LDCM0486  CL91 HEK-293T C320(1.74)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C320(1.98)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C320(3.92)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C320(1.64)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C320(2.03)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C320(1.78)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C320(1.45)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C320(1.13)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C320(0.88)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C176(1.13)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C176(1.03)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C320(0.92)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C320(0.98)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C320(1.12)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C320(0.87)  LDD1502  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402