Details of the Target
General Information of Target
| Target ID | LDTP14955 | |||||
|---|---|---|---|---|---|---|
| Target Name | Putative heat shock protein HSP 90-beta-3 (HSP90AB3P) | |||||
| Gene Name | HSP90AB3P | |||||
| Synonyms |
HSP90BC; Putative heat shock protein HSP 90-beta-3; Heat shock protein 90-beta c; Heat shock protein 90Bc |
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| 3D Structure | ||||||
| Sequence |
MLQLLVLKIEDPGCFWVIIKGCSPFLDHDVDYQKLNSAMNDFYNSTCQDIEIKPLTLEEG
QVCVVYCEELKCWCRAIVKSITSSADQYLAECFLVDFAKNIPVKSKNIRVVVESFMQLPY RAKKFSLYCTKPVTLHIDFCRDSTDIVPAKKWDNAAIQYFQNLLKATTQVEARLCAVEED TFEVYLYVTIKDEKVCVNDDLVAKNYACYMSPTKNKNLDYLEKPRLNIKSAPSFNKLNPA LTLWPMFLQGKDVQGMEDSHGVNFPAQSLQHTWCKGIVGDLRPTATAQDKAVKCNMDSLR DSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADPDVPEASALSQKSNEKPLRL TEKKEYDEKNSCVKLLQFLNPDPLRADGISDLQQLQKLKGLQPPVVVLRNKIKPCLTIDS SPLSADLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCESNPLLYLLPVLTVLQTG ACYKSLPSRNGPLAVIVCPGWKKAQFIFELLGEYSMSSRPLHPVLLTIGLHKEEAKNTKL PRGCDVIVTTPYSLLRLLACQSLLFLRLCHLILDEVEVLFLEANEQMFAILDNFKKNIEV EERESAPHQIVAVGVHWNKHIEHLIKEFMNDPYIVITAMEEAALYGNVQQVVHLCLECEK TSSLLQALDFIPSQAQKTLIFTCSVAETEIVCKVVESSSIFCLKMHKEMIFNLQNVLEQW KKKLSSGSQIILALTDDCVPLLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQGSP AEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAELYEFTAGVLEAKEDKKAGRPL CPYLKAFGFCKDKRICPDRHRINPETDLPRKLSSQALPSFGYIKIIPFYILNATNYFGRI VDKHMDLYATLNAEMNEYFKDSNKTTVEKVEKFGLYGLAEKTLFHRVQVLEVNQKEDAWA LDDILVEFIDEGRTGLVTRDQLLHLPEHFHTLPPQAVEFIVCRVKPADNEIEWNPKVTRY IHHKIVGKLHDAKVILALGNTVWIDPMVHITNLSSLKTSVIDYNVRAEILSMGMGIDNPE HIEQLKKLREDAKIPACEESLSQTPPRVTGTSPAQDQDHPSEEQGGQGTPPAEDAACLQS PQPEDTGAEGGAESKTSSENQKPGGYLVFKRWLSSNR |
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| Target Bioclass |
Other
|
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| Family |
Heat shock protein 90 family
|
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| Subcellular location |
Cytoplasm
|
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| Function | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. | |||||
| Uniprot ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
AZ-9 Probe Info |
 |
D61(0.85); E365(0.89); E166(0.89); E81(1.14) | LDD2208 | [1] | |
|
DBIA Probe Info |
 |
C521(7.23) | LDD3312 | [2] | |
|
HHS-475 Probe Info |
 |
Y56(0.71); Y492(0.82); Y298(0.86); Y195(1.08) | LDD0264 | [3] | |
|
HHS-465 Probe Info |
 |
Y171(10.00); Y190(10.00); Y195(1.13); Y492(10.00) | LDD2237 | [4] | |
|
Acrolein Probe Info |
 |
N.A. | LDD0221 | [5] | |
|
PF-06672131 Probe Info |
 |
N.A. | LDD0152 | [6] | |
|
STPyne Probe Info |
 |
K289(0.00); K404(0.00); K290(0.00) | LDD0009 | [7] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0116 | HHS-0101 | DM93 | Y56(0.71); Y492(0.82); Y298(0.86); Y195(1.08) | LDD0264 | [3] |
| LDCM0117 | HHS-0201 | DM93 | Y298(0.55); Y195(0.66); Y492(0.71); Y56(0.91) | LDD0265 | [3] |
| LDCM0118 | HHS-0301 | DM93 | Y56(0.62); Y298(0.77); Y492(0.81); Y195(1.09) | LDD0266 | [3] |
| LDCM0119 | HHS-0401 | DM93 | Y56(0.65); Y298(0.76); Y492(0.85); Y195(1.09) | LDD0267 | [3] |
| LDCM0120 | HHS-0701 | DM93 | Y56(0.70); Y298(0.71); Y492(0.85); Y195(0.91) | LDD0268 | [3] |
| LDCM0107 | IAA | HeLa | N.A. | LDD0221 | [5] |
| LDCM0022 | KB02 | 22RV1 | C521(1.46) | LDD2243 | [2] |
| LDCM0023 | KB03 | 22RV1 | C521(2.68) | LDD2660 | [2] |
| LDCM0024 | KB05 | HMCB | C521(7.23) | LDD3312 | [2] |
References