Details of the Target

General Information of Target

Target ID LDTP14948
Target Name Rho GTPase-activating protein 15 (ARHGAP15)
Gene Name ARHGAP15
Gene ID 55843
Synonyms
Rho GTPase-activating protein 15; ArhGAP15; Rho-type GTPase-activating protein 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALPGYPLGNVDDSRSKDSPAGEPQGQVPLTADVLAVSSSVASTDWQDIDQASFKTATPR
AISTSGDKDKSAVVPEHGQKTPRKITPLLPSQNPSPLQVSMSLQNPAWDRQVQDARTSQS
LVVFPSHLLGKDKMSQMASVPEREPESAPSAPSAELQSTQHMEAQPVESDADHVTAGANG
QHGPQAASTTKSAEEKAEHPKAPHPEAEALPSDESPVAMGANVVDSLGDLQTWFFPPPPA
GSVSPSPGPHEVALGRRPLDSSLYTASEENSYMRSMTSLLDRGEGSISSLADILVWSETT
MGMAIATGFLDSGHSTVADLLHSSGPSLRSVPSLVGSVSSAFSSGLVSGTSSALRTITRV
LETVEQRTVEGIRSAMRYLTSHLTPRQAQADPNYD
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.
Uniprot ID
Q53QZ3
Ensemble ID
ENST00000295095.11
HGNC ID
HGNC:21030

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K419(0.94)  LDD0277  [1]
DBIA
 Probe Info  		C197(1.56); C301(2.01)  LDD3334  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C197(0.00); C301(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C197(0.00); C301(0.00); C140(0.00)  LDD0036  [3]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [4]
Lodoacetamide azide
 Probe Info  		C301(0.00); C140(0.00)  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C197(0.98)  LDD2187  [5]
 LDCM0572  Fragment10 Ramos C197(1.61)  LDD2189  [5]
 LDCM0573  Fragment11 Ramos C197(5.25)  LDD2190  [5]
 LDCM0574  Fragment12 Ramos C197(1.01)  LDD2191  [5]
 LDCM0575  Fragment13 Ramos C197(0.95)  LDD2192  [5]
 LDCM0576  Fragment14 Ramos C197(1.46)  LDD2193  [5]
 LDCM0579  Fragment20 Ramos C197(1.51)  LDD2194  [5]
 LDCM0580  Fragment21 Ramos C197(0.86)  LDD2195  [5]
 LDCM0582  Fragment23 Ramos C197(0.90)  LDD2196  [5]
 LDCM0578  Fragment27 Ramos C197(0.85)  LDD2197  [5]
 LDCM0586  Fragment28 Ramos C197(0.82)  LDD2198  [5]
 LDCM0588  Fragment30 Ramos C197(1.02)  LDD2199  [5]
 LDCM0589  Fragment31 Ramos C197(0.90)  LDD2200  [5]
 LDCM0590  Fragment32 Ramos C197(2.23)  LDD2201  [5]
 LDCM0468  Fragment33 Ramos C197(1.12)  LDD2202  [5]
 LDCM0596  Fragment38 Ramos C197(0.86)  LDD2203  [5]
 LDCM0566  Fragment4 Ramos C197(1.12)  LDD2184  [5]
 LDCM0610  Fragment52 Ramos C197(1.24)  LDD2204  [5]
 LDCM0614  Fragment56 Ramos C197(1.73)  LDD2205  [5]
 LDCM0569  Fragment7 Ramos C197(0.24)  LDD2186  [5]
 LDCM0571  Fragment9 Ramos C197(1.67)  LDD2188  [5]
 LDCM0022  KB02 T cell-activated C287(5.09); C197(8.78)  LDD1704  [6]
 LDCM0023  KB03 Ramos C197(1.04)  LDD2183  [5]
 LDCM0024  KB05 MOLM-16 C197(1.56); C301(2.01)  LDD3334  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.