Details of the Target

General Information of Target

Target ID LDTP14902
Target Name Atos homolog protein A (ATOSA)
Gene Name ATOSA
Gene ID 56204
Synonyms
FAM214A; KIAA1370; Atos homolog protein A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEERKTAELQKNRIQDSVVFEDVAVDFTQEEWALLDLAQRNLYRDVMLENFQNLASLGY
PLHTPHLISQWEQEEDLQTVKRELIQGIFMGEHREGFETQLKTNESVASQDICGEKISNE
QKIVRFKRNDSWFSSLHENQESCGIDYQNKSHERHLRNHMVENIYECYEENQDGQTFSQV
PNLDSLKRNTEVKSCECHECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLACFKK
HMKTPTEEKPYECKECTKAFSCSSFFRAHMKIHIGKTNYECKECGKGFSCSSSLTEHKRI
HSGDKPYECKECGKAFSCSSSLSKHKRIHSGDKPYECKECGKAFSSSSHLIIHIRIHTGE
KPYECKECGKAFSESSKLTVHGRTHTGEKPYKCKECGKAYNCPSSLSIHMRKHTGEKPYE
CLECGKAFYLPTSLNTHVKNQSREKPYECKECGKAFSCPSSFRAHVRDHTGKIQYECKEC
GKTFSRSSSLTEHLRTHSGEKPYECKECGKAFISSSHLTVHIRTHTGEKPYECKKCGKAF
IYPSALRIHMRTHTGEKPYECKECGKAFRHSSYLTVHARMHTGEKPFECLECGKAFSCPS
SFRRHVRSHTGEKPYECKECGKAFVCPAYFRRHVKTHTRENI
Target Bioclass
Other
Family
ATOS family
Subcellular location
Nucleus
Function Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues.
Uniprot ID
Q32MH5
Ensemble ID
ENST00000261844.11
HGNC ID
HGNC:25609

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.H788R .
AN3CA Deletion: p.S157LfsTer3 .
CCSW1 SNV: p.I346V .
HCT116 Insertion: p.G421RfsTer2 .
JHH6 SNV: p.V485L .
LS180 SNV: p.S819I .
MCC13 Substitution: p.R151C .
MEWO SNV: p.P934S .
NCIH2172 SNV: p.E358K .
RL952 Insertion: p.S157FfsTer26
SNV: p.H390R		 .
SHSY5Y SNV: p.M427V .
SKMEL5 SNV: p.S338L .
SKNSH SNV: p.M427V .
SNU1 SNV: p.D707N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C576(1.07)  LDD2097  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C576(1.07)  LDD2097  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264