Details of the Target
General Information of Target
| Target ID | LDTP14852 | |||||
|---|---|---|---|---|---|---|
| Target Name | Translocating chain-associated membrane protein 2 (TRAM2) | |||||
| Gene Name | TRAM2 | |||||
| Gene ID | 9697 | |||||
| Synonyms |
KIAA0057; Translocating chain-associated membrane protein 2 |
|||||
| 3D Structure | ||||||
| Sequence |
MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL
NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA CGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFK YHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNA NTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILE QILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNP SKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKV NLKVKHVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQ AKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELS IHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDT CFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQE LLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQI SVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHP TVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYN LLDLPKYSSKEILSARLTQALDNYEGFSLA |
|||||
| Target Bioclass |
Transporter and channel
|
|||||
| Family |
TRAM family
|
|||||
| Subcellular location |
Membrane
|
|||||
| Function |
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT).
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K108(7.63) | LDD0277 | [1] | |
|
IA-alkyne Probe Info |
 |
C291(0.94) | LDD2187 | [2] | |
|
TFBX Probe Info |
 |
N.A. | LDD0027 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0625 | F8 | Ramos | C291(0.94) | LDD2187 | [2] |
| LDCM0573 | Fragment11 | Ramos | C291(0.30) | LDD2190 | [2] |
| LDCM0575 | Fragment13 | Ramos | C291(0.88) | LDD2192 | [2] |
| LDCM0580 | Fragment21 | Ramos | C291(0.87) | LDD2195 | [2] |
| LDCM0582 | Fragment23 | Ramos | C291(0.95) | LDD2196 | [2] |
| LDCM0578 | Fragment27 | Ramos | C291(0.75) | LDD2197 | [2] |
| LDCM0586 | Fragment28 | Ramos | C291(0.78) | LDD2198 | [2] |
| LDCM0588 | Fragment30 | Ramos | C291(1.10) | LDD2199 | [2] |
| LDCM0589 | Fragment31 | Ramos | C291(1.30) | LDD2200 | [2] |
| LDCM0590 | Fragment32 | Ramos | C291(0.98) | LDD2201 | [2] |
| LDCM0468 | Fragment33 | Ramos | C291(1.19) | LDD2202 | [2] |
| LDCM0596 | Fragment38 | Ramos | C291(1.45) | LDD2203 | [2] |
| LDCM0610 | Fragment52 | Ramos | C291(0.78) | LDD2204 | [2] |
| LDCM0614 | Fragment56 | Ramos | C291(0.52) | LDD2205 | [2] |
References