Details of the Target

General Information of Target

Target ID LDTP14818
Target Name Zinc finger protein 763 (ZNF763)
Gene Name ZNF763
Gene ID 284390
Synonyms
Zinc finger protein 763
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASAQVSVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQ
LDHRQELWMATKDLSQSSYPGDNTKPKTTEPTFSHLALPEEVLLQEQLTQGASKNSQLGQ
SKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSERDGLGSDDGVCTKITQKQVSTEGDLYE
CDSHGPVTDALIREEKNSYKCEECGKVFKKNALLVQHERIHTQVKPYECTECGKTFSKST
HLLQHLIIHTGEKPYKCMECGKAFNRRSHLTRHQRIHSGEKPYKCSECGKAFTHRSTFVL
HHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEKPYECIECGKAFNRRSYLTWHQQI
HTGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRRSHLKQHQRIHTGE
KPYECSECGKAFTHCSTFVLHKRTHTGEKPYECKECGKAFSDRADLIRHFSIHTGEKPYE
CVECGKAFNRSSHLTRHQQIHTGEKPYECIQCGKAFCRSANLIRHSIIHTGEKPYECSEC
GKAFNRGSSLTHHQRIHTGRNPTIVTDVGRPFMTAQTSVNIQELLLGKEFLNITTEENLW
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q0D2J5
Ensemble ID
ENST00000343949.9
HGNC ID
HGNC:27614

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 Substitution: p.V209F .
CAL78 Substitution: p.V209F .
CAMA1 SNV: p.H297Y .
CCFSTTG1 Substitution: p.V209F .
COLO792 SNV: p.L355F .
DEL Substitution: p.V209F .
DETROIT562 SNV: p.N118S .
DOTC24510 SNV: p.S270Y .
HT115 SNV: p.Y54C .
HT29 Substitution: p.V209F .
MINO Substitution: p.V209F .
NB4 Substitution: p.V209F .
RH30 Substitution: p.V209F .
SKES1 Substitution: p.V209F .
SW1271 SNV: p.P157H .
SW948 Substitution: p.V209F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C230(2.31)  LDD0170  [1]
DBIA
 Probe Info  		C211(6.16)  LDD0209  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C230(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C230(2.25)  LDD0171  [1]
 LDCM0023  KB03 Jurkat C211(6.16)  LDD0209  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) GADD45 family O95257
Suppressor of fused homolog (SUFU) SUFU family Q9UMX1

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.